Achuta Kadambi, Ph.D.

Achuta Kadambi received the PhD degree from MIT and joined UCLA as an Assistant Professor. His publications have been presented as Orals at CVPR, ICCV, ICCP and SIGGRAPH. He is currently co-authoring a textbook (“Computational Imaging”, MIT Press 2021) and is also a co-founder in a robotic imaging startup (http://akasha.im). Achuta’s research has received several recognitions including the NSF CAREER Award, Forbes 30 under 30 (Science), Google Faculty Award, Sony Imaging Young Faculty Award, and Army Young Investigator Award (ARO-YIP).

Carla Koehler, Ph.D.

Biography

Professor Koehler has been a faculty member in the Department of Chemistry and Biochemistry since 1999. She came to UCLA after doing post-doctoral research in the laboratory of Dr Gottfried Schatz at the Biozentrum, Basel, Switzerland. Her research characterized a new protein import pathway in the mitochondrion and linked a defect in protein import with the inherited disease deafness-dystonia syndrome. Dr. Koehler completed her graduate studies at Iowa State University, characterizing the inheritance of mitochondrial DNA during her M.S. studies and studying dimorphism in Saccharomyces cerevisiae . Dr. Koehler is a former Damon Runyon Scholar and current Established Investigator of the American Heart Association. Dr. Koehler is an Associate Editor for Current Genetics . She has been a member of the Molecular Biology Institute, Jonsson Cancer Center, and the Brain Research Institute since 1999. Her current research focuses on developing vertebrate models for mitochondrial diseases as well as using yeast for mechanistic studies on mitochondrial biogenesis.

Publications

A selected list of publications:

Dabir Deepa V, Hasson Samuel A, Setoguchi Kiyoko, Johnson Meghan E, Wongkongkathep Piriya, Douglas Colin J, Zimmerman Johannes, Damoiseaux Robert, Teitell Michael A, Koehler Carla M   A small molecule inhibitor of redox-regulated protein translocation into mitochondria Developmental cell, 2013; 25(1): 81-92.
Arango Nelson Alexander, Li Li, Dabir Deepa, Nicolau Fotini, Pieretti-Vanmarcke Rafael, Koehler Carla, McCarrey John R, Lu Naifang, Donahoe Patricia K   Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (M1ap)-deficient mice Biology of reproduction, 2013; 88(3): 76.
Zhang Jin, Nuebel Esther, Daley George Q, Koehler Carla M, Teitell Michael A   Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal Cell stem cell, 2012; 11(5): 589-95.
Bourens Myriam, Dabir Deepa V, Tienson Heather L, Sorokina Irina, Koehler Carla M, Barrientos Antoni   Role of twin Cys-Xaa9-Cys motif cysteines in mitochondrial import of the cytochrome C oxidase biogenesis factor Cmc1 The Journal of biological chemistry, 2012; 287(37): 31258-69.
Claypool Steven M, Koehler Carla M   The complexity of cardiolipin in health and disease Trends in biochemical sciences, 2012; 37(1): 32-41.
Claypool Steven M, Whited Kevin, Srijumnong Santi, Han Xianlin, Koehler Carla M   Barth syndrome mutations that cause tafazzin complex lability The Journal of cell biology, 2011; 192(3): 447-62.
Curado Silvia, Ober Elke A, Walsh Susan, Cortes-Hernandez Paulina, Verkade Heather, Koehler Carla M, Stainier Didier Y R   The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model Disease models & mechanisms, 2010; 3(7-8): 486-95.
Zaltsman Yehudit, Shachnai Liat, Yivgi-Ohana Natalie, Schwarz Michal, Maryanovich Maria, Houtkooper Riekelt H, Vaz Frédéric Maxime, De Leonardis Francesco, Fiermonte Giuseppe, Palmieri Ferdinando, Gillissen Bernhard, Daniel Peter T, Jimenez Erin, Walsh Susan, Koehler Carla M, Roy Soumya Sinha, Walter Ludivine, Hajnóczky György, Gross Atan   MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria Nature cell biology, 2010; 12(6): 553-62.
Hasson Samuel A, Damoiseaux Robert, Glavin Jenny D, Dabir Deepa V, Walker Scott S, Koehler Carla M   Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(21): 9578-83.
Tienson Heather L, Dabir Deepa V, Neal Sonya E, Loo Rachel, Hasson Samuel A, Boontheung Pinmanee, Kim Sung-Kun, Loo Joseph A, Koehler Carla M   Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins Molecular biology of the cell, 2009; 20(15): 3481-90.
Lu, G., H. Sun, P. Korge, C. M. Koehler, J. N. Weiss, and Y. Wang   Functional characterization of a mitochondrial Ser/Thr protein phosphatase in cell death regulation Methods Enzymol, 2009; 457: 255-273.
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Chacinska A., C. M. Koehler, D. Milenkovic, T. Lithgow, and N. Pfanner   Importing mitochondrial proteins: machineries and mechanisms Cell, 2009; 138: 628-644.
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Tienson, H. L., D. V. Dabir, S. E. Neal, R. Loo, S. A. Hasson, P. Boontheung, S.-K. Kim, J. A. Loo, and C. M. Koehler   Reconstitution of the Mia40-Erv1 oxidative folding pathway for the small Tim proteins Mol. Biol. Cell, 2009; 20: 3481-3490.
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Koehler, C. M. and H. L. Tienson   Redox regulation of protein folding in the mitochondrial intermembrane space Biochim Biophys Acta, 2009; 1793: 139-145.
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Koehler Carla M, Tienson Heather L   Redox regulation of protein folding in the mitochondrial intermembrane space Biochimica et biophysica acta, 2009; 1793(1): 139-45.
Claypool Steven M, Boontheung Pinmanee, McCaffery J Michael, Loo Joseph A, Koehler Carla M   The cardiolipin transacylase, tafazzin, associates with two distinct respiratory components providing insight into Barth syndrome Molecular biology of the cell, 2008; 19(12): 5143-55.
Beverly Kristen N, Sawaya Michael R, Schmid Einhard, Koehler Carla M   The Tim8-Tim13 complex has multiple substrate binding sites and binds cooperatively to Tim23 Journal of molecular biology, 2008; 382(5): 1144-56.
Claypool Steven M, Oktay Yavuz, Boontheung Pinmanee, Loo Joseph A, Koehler Carla M   Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane The Journal of cell biology, 2008; 182(5): 937-50.
Walsh Susan, Koehler Carla M   Gazing at translocation in the mitochondrion Cell, 2008; 134(3): 382-3.
Gebert, N., A. Chacinska, K. Wagner, B. Guiard, C. M. Koehler, P. Rehling, N. Pfanner, and N. Wiedemann   Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase EMBO Rep, 2008; 9: 548-554.
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Claypool, S. M., Y. Oktay, P. Boontheung, J. A. Loo, and C. M. Koehler   Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane J. Cell Biol, 2008; 182: 937-950.
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Walsh, S. and C. M. Koehler   Gazing at translocation in the mitochondrion Cell, 2008; 134: 382-383.
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Beverly, K. N., M, R. Sawaya, E. Schmid, and C. M. Koehler   The Tim8-Tim13 complex has multiple substrate binding sites and binds cooperatively to Tim23 J. Mol. Biol, 2008; 382: 1144-1156.
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Claypool, S. M., P. Boontheung, J. M. McCaffery, J. A. Loo, and C. M. Koehler   The cardiolipin transacylase, Tafazzin, associates with two distinct respiratory components providing insight into Barth syndrome Mol. Biol. Cell, 2008; 19: 5143-5155.
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Dabir Deepa V, Leverich Edward P, Kim Sung-Kun, Tsai Frederick D, Hirasawa Masakazu, Knaff David B, Koehler Carla M   A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1 The EMBO journal, 2007; 26(23): 4801-11.
Hwang David K, Claypool Steven M, Leuenberger Danielle, Tienson Heather L, Koehler Carla M   Tim54p connects inner membrane assembly and proteolytic pathways in the mitochondrion The Journal of cell biology, 2007; 178(7): 1161-75.
Lu G., Ren S., Korge P., Choi J., Dong Y., Weiss J., Koehler C., Chen J.N., Wang Y.   A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development Genes Dev, 2007; 21: 784-796.
Dabir, D. V., E. P. Leverich, S.-K. Kim, F. D. Tsai, M. Hirasawa, D. B. Knaff, and C. M. Koehler   A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1, EMBO J, 2007; 26: 4801-4811.
Sediva, A., C. I. E. Smith, A. C. Asplund, J. Hadac, A. Janda, J. Zeman, H. Hansikova; L. Dvorakova, L. Mrazova, S. Velbri, C. Koehler, K. Roesch, K. E. Sullivan, T. Futatani, H. Ochs   Contiguous X-chromosome deletion syndrome encompassing the BTK, TIMM8A, TAF7L and DRP2 genes, J. Clin. Immunol. , 2007; 27: 640-646.
Chen, H.-W., C. M. Koehler, and M. A. Teitell   Human polynucleotide phosphorylase: Location matters, Trends Cell Biol, 2007; 17: 600-608.
Stuart, R.A. and C.M. Koehler   In Vitro Analysis of Yeast Mitochondrial Protein Import, In Morgan, K. (ed.) Current Protocols in Cell Biology, 2007; 11.19.1-11.19.20.
French S.W., Dawson D.W., Chen H.W., Rainey R.N., Sievers S.A., Balatoni C.E., Wong L., Troke J.J., Nguyen M.T., Koehler C.M., Teitell M.A.   The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity Cancer Letts, 2007; 248: 198-210.
Oktay, Y., R.N.Rainey, and C.M. Koehler   The function of TIM22 in the insertion of inner membrane proteins in mitochondria, Dalbey, R.E., Koehler, C.M., and Tamanoi, F. (eds.) The Enzymes: Molecular Machines Involved in Protein Transport across Membrane, 2007; 25: 367-386.
Hwang, D. K., S. M. Claypool, H. D. Tienson, D. Leuenberger, C. M. Koehler   Tim54p mediates assembly of the i-AAA protease Yme1p, J. Cell Biol. , 2007; 178: 1161-75.
Claypool Steven M, McCaffery J Michael, Koehler Carla M   Mitochondrial mislocalization and altered assembly of a cluster of Barth syndrome mutant tafazzins The Journal of cell biology, 2006; 174(3): 379-90.
Rainey R.N., Glavin J.D., Chen H.W., French S.W., Teitell M.A., Koehler C.M.   A new function in translocation for the mitochondrial i-AAA protease Yme1: import of polynucleotide phosphorylase into the intermembrane space Mol. Cell. Biol, 2006; 26(22): 8488-8497.
Chen, H.W., Rainey, R.N., Balatoni C.E., Dawson D.W., Troke J.J., Wasiak S., Hong J.S., McBride H.M., Koehler C.M., Teitell M.A., French S.W.   Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis Mol. Cell. Biol, 2006; 26(22): 8475-8487.
Claypool, S.M., McCaffery, J.M., Koehler, C.M.   Mitochondrial mislocalization and altered assembly of a cluster of Barth syndrome mutant tafazzins, J. Cell Biol, 2006; 184: 379-390.
Koehler, C.M., Beverly, K.N., Leverich, E.P.   Redox Pathways of the Mitochondrion, Antioxid. Redox. Signal, 2006; 8: 813-822.
Claypool SM, Koehler CM   Hereditary spastic paraplegia: respiratory choke or unactivated substrate? Cell. , 2005; 123(2): 183-5.
Claypool Steven M, Koehler Carla M   Hereditary spastic paraplegia: respiratory choke or unactivated substrate? Cell, 2005; 123(2): 183-5.
Likic VA, Perry A, Hulett J,Derby M, Traven A, Waller RF, Keeling PJ, Koehler CM, Curran SP, Gooley PR and Lithgow T   Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20 J. Mol. Biol, 2005; 347: 81-93.
Koehler CM, Hwang DK   Protein translocation across membranes, Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2005; 11: 287-308.
Curran SP, Leverich EP, Koehler CM, Larsen PL   Defective mitochondrial protein translocation precludes normal Caenorhabditis elegans development The Journal of biological chemistry. , 2004; 279(52): 54655-62.
Curran SP, Leuenberger D, Leverich EP, Hwang DK, Beverly KN, Koehler CM   The role of Hot13p and redox chemistry in the mitochondrial TIM22 import pathway The Journal of biological chemistry. , 2004; 279(42): 43744-51.
Curran SP and Koehler CM   Mitochondrial biogenesis. Protein import into and across the inner membrane, Topics in Current Genetics: Mitochondrial Function and Biogenesis, 2004; 8: 59-80.
Koehler CM   New developments in mitochondrial assembly Annual review of cell and developmental biology. , 2004; 20: 309-35.
Leuenberger D, Curran SP and Koehler CM   Structure, bioenergetics, and biogenesis of mitochondria, The Biogenesis of Cellular Organelles, 2004; 138-163.
Roesch K, Hynds PH, Varga R, Tranebjaerg L and Koehler CM   The calcium-binding apartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex Hum. Mol. Gen, 2004; 13: 2101-2111.
Koehler CM   The small Tim proteins and the twin Cx3C motif Trends in biochemical sciences. , 2004; 29(1): 1-4.
Koehler CM   Import and assembly, Genetics of Mitochondrial Diseases, 2003; 47-68.
Dyall SD, Lester DC, Schneider RE, Delgadillo-Correa MG, Plumper E, Martinez A, Koehler CM, Johnson PJ   Trichomonas vaginalis Hmp35, a putative pore-forming hydrogenosomal membrane protein, can form a complex in yeast mitochondria J. Biol. Chem, 2003; 278: 30548-30461.
van der Bliek AM, Koehler CM   A mitochondrial rhomboid protease Developmental cell. , 2003; 4(6): 769-70.
Leuenberger D, Curran SP, Wong D, Koehler CM   The role of Tim9p in the assembly of the TIM22 import complexes Traffic (Copenhagen, Denmark) , 2003; 4(3): 144-52.
Curran SP, Leuenberger D, Schmidt E, Koehler CM   The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins The Journal of cell biology. , 2002; 158(6): 1017-27.
Roesch K, Tranejaerg L, Koehler CM   How do defects in mitochondrial protein import lead to deafness, 19th Danavox Symposium: Genetics and the function of the auditory system. , 2002; 19: 139-154.
Roesch K, Curran SP, Tranebjaerg L and Koehler CM   Human deafness dystonia syndrome is caused by a defect in asssembly of the DDP1/TIMM8a-TIMM13 complex Hum. Mol. Gent, 2002; 11: 477-486.
Curran SP, Leuenberger D, Oppliger W, Koehler CM   The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier The EMBO journal. , 2002; 21(5): 942-53.
Murphy MP, Leuenberger D, Curran SP, Oppliger W and Koehler CM   The essential function of the small tim proteins in the tim22 import pathway does not depend on formation of the soluble 70-kilodalton complex Mol. Cell. Biol, 2001; 21: 6132-6138.
Renold A, Koehler CM and Murphy MP   Mitochondrial import of the long and short isoforms of human uncoupling protein 3 FEBS Lett, 2000; 465: 135-140.
Koehler CM   Protein translocation pathways of the mitochondrion FEBS Lett, 2000; 476(1-2): 27-31.
Dyall SM, Koehler CM, Delgadillo MG, Bradley PJ, Plumper E, Leuenberger D, Turck CW and Johnson PJ   The presence of mitochondria carrier in the hydrogenosomal membranes: conservation of membrane targeting pathways indicated a progenitor organelle gave rise to hydrogenosomes and mitochondria Mol. Cell. Biol, 2000; 20: 2488-2497.
Koehler CM, Murphy MP, Bally NA, Oppliger W, Dolfini L, Junne T and Or E   Tim18p, a novel subunit of the inner membrane complex that mediates protein import into the yeast mitochondrial inner membrane Mol. Cell. Biol, 2000; 20: 1187-1193.
Patterson SD, Spahr CS, Daugas E, Susin SA, Irinopoulou T, Koehler C, Kroemer G   Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition Cell death and differentiation. , 2000; 7(2): 137-44.
Koehler CM, Merchant S, Schatz G   How membrane proteins travel across the mitochondrial intermembrane space Trends in biochemical sciences. , 1999; 24(11): 428-32.
Leuenberger D, Bally NA, Schatz G, Koehler CM   Different import pathways through the mitochondrial intermembrane space for inner membrane proteins The EMBO journal. , 1999; 18(17): 4816-22.
Koehler CM, Leuenberger D, Merchant S, Renold A, Junne T and Schatz G   Human deafness dystonia syndrome is a mitochondrial disease Proc. Natl. Acad. Sci. (USA), 1999; 96: 2141-2146.
Komiya T, Rospert S, Koehler CM, Looser R, Schatz G, and Mihara K   Interaction of mitochondrial targeting signals with acidic receptor domains along the protein import pathway: Evidence for the “acid chain” hypothesis, EMBO J, 1998; 17: 3886-3898.
Koehler CM, Merchant S, Oppliger W, Schmid K, Jarosch E, Dolfini L, Junne T, Schatz G and Tokatlidis K   Tim9p, an essential partner of Tim10p for the import of mitochondrial carriers EMBO J, 1998; 17: 6477-6486.
Koehler CM, Jarosch E, Tokatlidis K, Schmid K, Schweyen RJ, Schatz G   Import of mitochondrial carriers mediated by essential proteins of the intermembrane space Science. , 1998; 279(5349): 369-73.
Blacketer MJ, Koehler CM, Coats SG, Myers AM, Madaule P   Regulation of dimorphism in Saccharomyces cerevisiae: involvement of the novel protein kinase homolog Elm1p and protein phosphatase 2A Molecular and cellular biology. , 1993; 13(9): 5567-81.
Koehler CM, Lindber GL, BrownDR, Beitz DC, Freeman AE, Mayfield JE and Myers AM   Replacement of bovine mitochondrial DNA by a sequence variant within a single generation, Genetics, 1991; 129: 247-255.

Katherine Karlsgodt, Ph.D.

Publications

A selected list of publications:

Barber Anita D, Lindquist Martin A, DeRosse Pamela, Karlsgodt Katherine H   Dynamic Functional Connectivity States Reflecting Psychotic-like Experiences Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018; 3(5): 443-453.
Uddin Lucina Q, Karlsgodt Katherine H   Future Directions for Examination of Brain Networks in Neurodevelopmental Disorders Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53, 2018; 47(3): 483-497.
Blair Melanie A, Nitzburg George, DeRosse Pamela, Karlsgodt Katherine H   Relationship between executive function, attachment style, and psychotic like experiences in typically developing youth Schizophrenia research, 2018; 47(3): 483-497.
Karlsgodt Katherine H, Bato Angelica A, Ikuta Toshikazu, Peters Bart D, DeRosse Pamela, Szeszko Philip R, Malhotra Anil K   Functional Activation During a Cognitive Control Task in Healthy Youth Specific to Externalizing or Internalizing Behaviors Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018; 3(2): 133-140.
Ikuta Toshikazu, Del Arco Alberto, Karlsgodt Katherine H   White matter integrity in the fronto-striatal accumbofrontal tract predicts impulsivity Brain imaging and behavior, 2018; 3(2): 133-140.
Eckfeld Ariel, Karlsgodt Katherine H, Haut Kristen M, Bachman Peter, Jalbrzikowski Maria, Zinberg Jamie, van Erp Theo G M, Cannon Tyrone D, Bearden Carrie E   Disrupted Working Memory Circuitry in Adolescent Psychosis Frontiers in human neuroscience, 2017; 11(11): 394.
Sarpal Deepak K, Robinson Delbert G, Fales Christina, Lencz Todd, Argyelan Miklos, Karlsgodt Katherine H, Gallego Juan A, John Majnu, Kane John M, Szeszko Philip R, Malhotra Anil K   Relationship between Duration of Untreated Psychosis and Intrinsic Corticostriatal Connectivity in Patients with Early Phase Schizophrenia Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017; 42(11): 2214-2221.
Ibrahim Amira F A, Montojo Caroline A, Haut Kristen M, Karlsgodt Katherine H, Hansen Laura, Congdon Eliza, Rosser Tena, Bilder Robert M, Silva Alcino J, Bearden Carrie E   Spatial working memory in neurofibromatosis 1: Altered neural activity and functional connectivity NeuroImage. Clinical, 2017; 15(11): 801-811.
Schreiner Matthew, Forsyth Jennifer K, Karlsgodt Katherine H, Anderson Ariana E, Hirsh Nurit, Kushan Leila, Uddin Lucina Q, Mattiacio Leah, Coman Ioana L, Kates Wendy R, Bearden Carrie E   Intrinsic Connectivity Network-Based Classification and Detection of Psychotic Symptoms in Youth With 22q11.2 Deletions Cerebral cortex (New York, N.Y. : 1991), 2017; 27(6): 3294-3306.
Chang Eric H, Argyelan Miklos, Aggarwal Manisha, Chandon Toni-Shay S, Karlsgodt Katherine H, Mori Susumu, Malhotra Anil K   Diffusion tensor imaging measures of white matter compared to myelin basic protein immunofluorescence in tissue cleared intact brains Data in brief, 2017; 10(1): 438-443.
Chang Eric H, Argyelan Miklos, Aggarwal Manisha, Chandon Toni-Shay S, Karlsgodt Katherine H, Mori Susumu, Malhotra Anil K   The role of myelination in measures of white matter integrity: Combination of diffusion tensor imaging and two-photon microscopy of CLARITY intact brains NeuroImage, 2017; 147(6): 253-261.
DeRosse Pamela, Ikuta Toshikazu, Karlsgodt Katherine H, Peters Bart D, Gopin Chaya B, Szeszko Philip R, Malhotra Anil K   White Matter Abnormalities Associated With Subsyndromal Psychotic-Like Symptoms Predict Later Social Competence in Children and Adolescents Schizophrenia bulletin, 2017; 43(1): 152-159.
Schwehm Andrew, Robinson Delbert G, Gallego Juan A, Karlsgodt Katherine H, Ikuta Toshikazu, Peters Bart D, Malhotra Anil K, Szeszko Philip R   Age and Sex Effects on White Matter Tracts in Psychosis from Adolescence through Middle Adulthood Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016; 41(10): 2473-80.
Karlsgodt Katherine H   Diffusion Imaging of White Matter In Schizophrenia: Progress and Future Directions Biological psychiatry. Cognitive neuroscience and neuroimaging, 2016; 1(3): 209-217.
Sarpal Deepak K, Argyelan Miklos, Robinson Delbert G, Szeszko Philip R, Karlsgodt Katherine H, John Majnu, Weissman Noah, Gallego Juan A, Kane John M, Lencz Todd, Malhotra Anil K   Baseline Striatal Functional Connectivity as a Predictor of Response to Antipsychotic Drug Treatment The American journal of psychiatry, 2016; 173(1): 69-77.
Ikuta Toshikazu, DeRosse Pamela, Argyelan Miklos, Karlsgodt Katherine H, Kingsley Peter B, Szeszko Philip R, Malhotra Anil K   Subcortical modulation in auditory processing and auditory hallucinations Behavioural brain research, 2015; 295(1): 78-81.
Karlsgodt Katherine H, John Majnu, Ikuta Toshikazu, Rigoard Philippe, Peters Bart D, Derosse Pamela, Malhotra Anil K, Szeszko Philip R   The accumbofrontal tract: Diffusion tensor imaging characterization and developmental change from childhood to adulthood Human brain mapping, 2015; 36(12): 4954-63.
Haut Kristen M, Karlsgodt Katherine H, Bilder Robert M, Congdon Eliza, Freimer Nelson B, London Edythe D, Sabb Fred W, Ventura Joseph, Cannon Tyrone D   Memory systems in schizophrenia: Modularity is preserved but deficits are generalized Schizophrenia research, 2015; 168(1-2): 223-30.
Karlsgodt Katherine H, Bato Angelica A, Blair Melanie A, DeRosse Pamela, Szeszko Philip R, Malhotra Anil K   White matter microstructure in the executive network associated with aggression in healthy adolescents and young adults Social cognitive and affective neuroscience, 2015; 10(9): 1251-6.
DeRosse Pamela, Karlsgodt Katherine H   Examining the Psychosis Continuum Current behavioral neuroscience reports, 2015; 2(2): 80-89.
Sarpal Deepak K, Robinson Delbert G, Lencz Todd, Argyelan Miklos, Ikuta Toshikazu, Karlsgodt Katherine, Gallego Juan A, Kane John M, Szeszko Philip R, Malhotra Anil K   Antipsychotic treatment and functional connectivity of the striatum in first-episode schizophrenia JAMA psychiatry, 2015; 72(1): 5-13.
Peters Bart D, Karlsgodt Katherine H   White matter development in the early stages of psychosis Schizophrenia research, 2015; 161(1): 61-9.
DeRosse Pamela, Ikuta Toshikazu, Peters Bart D, Karlsgodt Katherine H, Szeszko Philip R, Malhotra Anil K   Adding insult to injury: childhood and adolescent risk factors for psychosis predict lower fractional anisotropy in the superior longitudinal fasciculus in healthy adults Psychiatry research, 2014; 224(3): 296-302.
Jalbrzikowski Maria, Villalon-Reina Julio E, Karlsgodt Katherine H, Senturk Damla, Chow Carolyn, Thompson Paul M, Bearden Carrie E   Altered white matter microstructure is associated with social cognition and psychotic symptoms in 22q11.2 microdeletion syndrome Frontiers in behavioral neuroscience, 2014; 8(3): 393.
Schreiner Matthew J, Karlsgodt Katherine H, Uddin Lucina Q, Chow Carolyn, Congdon Eliza, Jalbrzikowski Maria, Bearden Carrie E   Default mode network connectivity and reciprocal social behavior in 22q11.2 deletion syndrome Social cognitive and affective neuroscience, 2014; 9(9): 1261-7.
White Corey N, Congdon Eliza, Mumford Jeanette A, Karlsgodt Katherine H, Sabb Fred W, Freimer Nelson B, London Edythe D, Cannon Tyrone D, Bilder Robert M, Poldrack Russell A   Decomposing decision components in the stop-signal task: a model-based approach to individual differences in inhibitory control Journal of cognitive neuroscience, 2014; 26(8): 1601-14.
Peters Bart D, Voineskos Aristotle N, Szeszko Philip R, Lett Tristram A, DeRosse Pamela, Guha Saurav, Karlsgodt Katherine H, Ikuta Toshikazu, Felsky Daniel, John Majnu, Rotenberg David J, Kennedy James L, Lencz Todd, Malhotra Anil K   Brain white matter development is associated with a human-specific haplotype increasing the synthesis of long chain fatty acids The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014; 34(18): 6367-76.
Congdon Eliza, Altshuler Lori L, Mumford Jeanette A, Karlsgodt Katherine H, Sabb Fred W, Ventura Joseph, McGough James J, London Edythe D, Cannon Tyrone D, Bilder Robert M, Poldrack Russell A   Neural activation during response inhibition in adult attention-deficit/hyperactivity disorder: preliminary findings on the effects of medication and symptom severity Psychiatry research, 2014; 222(1-2): 17-28.
Helfinstein Sarah M, Schonberg Tom, Congdon Eliza, Karlsgodt Katherine H, Mumford Jeanette A, Sabb Fred W, Cannon Tyrone D, London Edythe D, Bilder Robert M, Poldrack Russell A   Predicting risky choices from brain activity patterns Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(7): 2470-5.
Karlsgodt Katherine H, van Erp Theo G M, Bearden Carrie E, Cannon Tyrone D   Altered relationships between age and functional brain activation in adolescents at clinical high risk for psychosis Psychiatry research, 2014; 221(1): 21-9.
Congdon Eliza, Bato Angelica A, Schonberg Tom, Mumford Jeanette A, Karlsgodt Katherine H, Sabb Fred W, London Edythe D, Cannon Tyrone D, Bilder Robert M, Poldrack Russell A   Differences in neural activation as a function of risk-taking task parameters Frontiers in neuroscience, 2013; 7(1): 173.
Bearden Carrie E, Karlsgodt Katherine H, Bachman Peter, van Erp Theo G M, Winkler Anderson M, Glahn David C   Genetic architecture of declarative memory: implications for complex illnesses The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2012; 18(5): 516-32.
Karlsgodt Katherine H, Rosser Tena, Lutkenhoff Evan S, Cannon Tyrone D, Silva Alcino, Bearden Carrie E   Alterations in white matter microstructure in neurofibromatosis-1 PloS one, 2012; 7(10): e47854.
Lutkenhoff Evan, Karlsgodt Katherine H, Gutman Boris, Stein Jason L, Thompson Paul M, Cannon Tyrone D, Jentsch J David   Structural and functional neuroimaging phenotypes in dysbindin mutant mice NeuroImage, 2012; 62(1): 120-9.
Karlsgodt Katherine H, Jacobson Sarah C, Seal Marc, Fusar-Poli Paolo   The relationship of developmental changes in white matter to the onset of psychosis Current pharmaceutical design, 2012; 18(4): 422-33.
Gee Dylan G, Karlsgodt Katherine H, van Erp Theo G M, Bearden Carrie E, Lieberman Matthew D, Belger Aysenil, Perkins Diana O, Olvet Doreen M, Cornblatt Barbara A, Constable Todd, Woods Scott W, Addington Jean, Cadenhead Kristin S, McGlashan Thomas H, Seidman Larry J, Tsuang Ming T, Walker Elaine F, Cannon Tyrone D, Cannon Tyrone D   Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: a preliminary study Schizophrenia research, 2012; 134(1): 1-9.
Karlsgodt Katherine H, Bachman Peter, Winkler Anderson M, Bearden Carrie E, Glahn David C   Genetic influence on the working memory circuitry: behavior, structure, function and extensions to illness Behavioural brain research, 2011; 225(2): 610-22.
Karlsgodt Katherine H, Robleto Karla, Trantham-Davidson Heather, Jairl Corey, Cannon Tyrone D, Lavin Antonieta, Jentsch J David   Reduced dysbindin expression mediates N-methyl-D-aspartate receptor hypofunction and impaired working memory performance Biological psychiatry, 2011; 69(1): 28-34.
Mittal Vijay A, Karlsgodt Katherine, Zinberg Jamie, Cannon Tyrone D, Bearden Carrie E   Identification and treatment of a pineal region tumor in an adolescent with prodromal psychotic symptoms The American journal of psychiatry, 2010; 167(9): 1033-7.
Karlsgodt Katherine H, Sun Daqiang, Cannon Tyrone D   Structural and Functional Brain Abnormalities in Schizophrenia Current directions in psychological science, 2010; 19(4): 226-231.
Shilyansky Carrie, Karlsgodt Katherine H, Cummings Damian M, Sidiropoulou Kyriaki, Hardt Molly, James Alex S, Ehninger Dan, Bearden Carrie E, Poirazi Panayiota, Jentsch J David, Cannon Tyrone D, Levine Michael S, Silva Alcino J   Neurofibromin regulates corticostriatal inhibitory networks during working memory performance Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(29): 13141-6.
Karlsgodt Katherine H, Kochunov Peter, Winkler Anderson M, Laird Angela R, Almasy Laura, Duggirala Ravindranath, Olvera Rene L, Fox Peter T, Blangero John, Glahn David C   A multimodal assessment of the genetic control over working memory The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(24): 8197-202.
Sanz Jacqueline H, Karlsgodt Katherine H, Bearden Carrie E, van Erp Theo G M, Nandy Rajesh R, Ventura Joseph, Nuechterlein Keith, Cannon Tyrone D   Symptomatic and functional correlates of regional brain physiology during working memory processing in patients with recent onset schizophrenia Psychiatry research, 2009; 173(3): 177-82.
Karlsgodt Katherine H, Niendam Tara A, Bearden Carrie E, Cannon Tyrone D   White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis Biological psychiatry, 2009; 66(6): 562-9.
Karlsgodt Katherine H, Sanz Jacqueline, van Erp Theo G M, Bearden Carrie E, Nuechterlein Keith H, Cannon Tyrone D   Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia Schizophrenia research, 2009; 108(1-3): 143-50.
Karlsgodt Katherine H, Sun Daqiang, Jimenez Amy M, Lutkenhoff Evan S, Willhite Rachael, van Erp Theo G M, Cannon Tyrone D   Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia Development and psychopathology, 2008; 20(4): 1297-327.
Karlsgodt Katherine H, van Erp Theo G M, Poldrack Russell A, Bearden Carrie E, Nuechterlein Keith H, Cannon Tyrone D   Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia Biological psychiatry, 2008; 63(5): 512-8.
van Erp Theo G M, Lesh Tyler A, Knowlton Barbara J, Bearden Carrie E, Hardt Molly, Karlsgodt Katherine H, Shirinyan David, Rao Vikas, Green Michael F, Subotnik Kenneth L, Nuechterlein Keith, Cannon Tyrone D   Remember and know judgments during recognition in chronic schizophrenia Schizophrenia research, 2008; 100(1-3): 181-90.
Yamamoto Rinah T, Karlsgodt Katherine H, Rott David, Lukas Scott E, Elman Igor   Effects of perceived cocaine availability on subjective and objective responses to the drug Substance abuse treatment, prevention, and policy, 2007; 2(1-3): 30.
Karlsgodt Katherine H, Glahn David C, van Erp Theo G M, Therman Sebastian, Huttunen Matti, Manninen Marko, Kaprio Jaakko, Cohen Mark S, Lönnqvist Jouko, Cannon Tyrone D   The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects Schizophrenia research, 2007; 89(1-3): 191-7.
Cannon Tyrone D, Glahn David C, Kim Junghoon, Van Erp Theo G M, Karlsgodt Katherine, Cohen Mark S, Nuechterlein Keith H, Bava Sunita, Shirinyan David   Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia Archives of general psychiatry, 2005; 62(10): 1071-80.
Karlsgodt Katherine H, Shirinyan David, van Erp Theo G M, Cohen Mark S, Cannon Tyrone D   Hippocampal activations during encoding and retrieval in a verbal working memory paradigm NeuroImage, 2005; 25(4): 1224-31.
Elman Igor, Lukas Scott E, Karlsgodt Katherine H, Gasic Gregory P, Breiter Hans C   Acute cortisol administration triggers craving in individuals with cocaine dependence Psychopharmacology bulletin, 2003; 37(3): 84-9.
Karlsgodt Katherine H, Lukas Scott E, Elman Igor   Psychosocial stress and the duration of cocaine use in non-treatment seeking individuals with cocaine dependence The American journal of drug and alcohol abuse, 2003; 29(3): 539-51.
Elman Igor, Karlsgodt Katherine H, Gastfriend David R, Chabris Christopher F, Breiter Hans C   Cocaine-primed craving and its relationship to depressive symptomatology in individuals with cocaine dependence Journal of psychopharmacology (Oxford, England), 2002; 16(2): 163-7.

Barbara Knowlton, Ph.D.

Biography

Barbara Knowlton received a B.A. in Psychology from Johns Hopkins University, and a Ph.D. in Neuroscience from Stanford University. She completed post-doctoral work in the Department of Psychiatry at UC San Diego.

Publications

A selected list of publications:

Wagshal, D. Knowlton, BJ, Cohen, JR, Bookheimer,SY, Bilder, RM Fernandez, VG, Asarnow, RF   Cognitive correlates of gray matter abnormalities in adolescent siblings of patients with childhood-onset schizophrenia Schizophrenia Research, 2015; 161: 345-350.
Haut KM, van Erp TG, Knowlton B, Bearden CE, Subotnik K, Ventura J, Nuechterlein KH, Cannon TD.   Contributions of Feature Binding During Encoding and Functional Connectivity of the Medial Temporal Lobe Structures to Episodic Memory Deficits Across the Prodromal and First-Episode Phases of Schizophrenia Clinical Psychological Science, 2015; 3(2): 159-174.
Suthana, NA, Donix, M, Wozny, DR, Bazih, A, Jones, M, Heidemann, RM, Trampel, R, Ekstrom, AD, Scharf, M, Knowlton, B, Turner, R Bookheimer, SY.   High-resolution 7T fMRI of Human Hippocampal Subfields during Associative Learning Journal of Cognitive Neuroscience, 2015; 27(6): 1194-1206.
Suthana, N.A., Parikshank, N.N., Ekstrom, A.D., Ison, M.J., Knowlton, B.J., Bookheimer, S.Y., Fried, I.   Specific Responses of Human Hippocampal Neurons are Associated with Better Memory Proceedings of the National Academy of Sciences, 2015; 112(33): 10503-10508.