Professor Koehler has been a faculty member in the Department of Chemistry and Biochemistry since 1999. She came to UCLA after doing post-doctoral research in the laboratory of Dr Gottfried Schatz at the Biozentrum, Basel, Switzerland. Her research characterized a new protein import pathway in the mitochondrion and linked a defect in protein import with the inherited disease deafness-dystonia syndrome. Dr. Koehler completed her graduate studies at Iowa State University, characterizing the inheritance of mitochondrial DNA during her M.S. studies and studying dimorphism in Saccharomyces cerevisiae . Dr. Koehler is a former Damon Runyon Scholar and current Established Investigator of the American Heart Association. Dr. Koehler is an Associate Editor for Current Genetics . She has been a member of the Molecular Biology Institute, Jonsson Cancer Center, and the Brain Research Institute since 1999. Her current research focuses on developing vertebrate models for mitochondrial diseases as well as using yeast for mechanistic studies on mitochondrial biogenesis.
A selected list of publications:
Dabir Deepa V, Hasson Samuel A, Setoguchi Kiyoko, Johnson Meghan E, Wongkongkathep Piriya, Douglas Colin J, Zimmerman Johannes, Damoiseaux Robert, Teitell Michael A, Koehler Carla M A small molecule inhibitor of redox-regulated protein translocation into mitochondria
Developmental cell, 2013; 25(1): 81-92.
Zaltsman Yehudit, Shachnai Liat, Yivgi-Ohana Natalie, Schwarz Michal, Maryanovich Maria, Houtkooper Riekelt H, Vaz FrÃ©dÃ©ric Maxime, De Leonardis Francesco, Fiermonte Giuseppe, Palmieri Ferdinando, Gillissen Bernhard, Daniel Peter T, Jimenez Erin, Walsh Susan, Koehler Carla M, Roy Soumya Sinha, Walter Ludivine, HajnÃ³czky GyÃ¶rgy, Gross Atan MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria
Nature cell biology, 2010; 12(6): 553-62.
Tienson, H. L., D. V. Dabir, S. E. Neal, R. Loo, S. A. Hasson, P. Boontheung, S.-K. Kim, J. A. Loo, and C. M. Koehler Reconstitution of the Mia40-Erv1 oxidative folding pathway for the small Tim proteins
Mol. Biol. Cell, 2009; 20: 3481-3490.
Dabir, D. V., E. P. Leverich, S.-K. Kim, F. D. Tsai, M. Hirasawa, D. B. Knaff, and C. M. Koehler A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1, EMBO J, 2007; 26: 4801-4811.
Sediva, A., C. I. E. Smith, A. C. Asplund, J. Hadac, A. Janda, J. Zeman, H. Hansikova; L. Dvorakova, L. Mrazova, S. Velbri, C. Koehler, K. Roesch, K. E. Sullivan, T. Futatani, H. Ochs Contiguous X-chromosome deletion syndrome encompassing the BTK, TIMM8A, TAF7L and DRP2 genes, J. Clin. Immunol. , 2007; 27: 640-646.
Chen, H.-W., C. M. Koehler, and M. A. Teitell Human polynucleotide phosphorylase: Location matters, Trends Cell Biol, 2007; 17: 600-608.
Stuart, R.A. and C.M. Koehler In Vitro Analysis of Yeast Mitochondrial Protein Import, In Morgan, K. (ed.) Current Protocols in Cell Biology, 2007; 11.19.1-11.19.20.
French S.W., Dawson D.W., Chen H.W., Rainey R.N., Sievers S.A., Balatoni C.E., Wong L., Troke J.J., Nguyen M.T., Koehler C.M., Teitell M.A. The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity
Cancer Letts, 2007; 248: 198-210.
Oktay, Y., R.N.Rainey, and C.M. Koehler The function of TIM22 in the insertion of inner membrane proteins in mitochondria, Dalbey, R.E., Koehler, C.M., and Tamanoi, F. (eds.) The Enzymes: Molecular Machines Involved in Protein Transport across Membrane, 2007; 25: 367-386.
Hwang, D. K., S. M. Claypool, H. D. Tienson, D. Leuenberger, C. M. Koehler Tim54p mediates assembly of the i-AAA protease Yme1p, J. Cell Biol. , 2007; 178: 1161-75.
Chen, H.W., Rainey, R.N., Balatoni C.E., Dawson D.W., Troke J.J., Wasiak S., Hong J.S., McBride H.M., Koehler C.M., Teitell M.A., French S.W. Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis
Mol. Cell. Biol, 2006; 26(22): 8475-8487.
Claypool, S.M., McCaffery, J.M., Koehler, C.M. Mitochondrial mislocalization and altered assembly of a cluster of Barth syndrome mutant tafazzins, J. Cell Biol, 2006; 184: 379-390.
Koehler, C.M., Beverly, K.N., Leverich, E.P. Redox Pathways of the Mitochondrion, Antioxid. Redox. Signal, 2006; 8: 813-822.
Likic VA, Perry A, Hulett J,Derby M, Traven A, Waller RF, Keeling PJ, Koehler CM, Curran SP, Gooley PR and Lithgow T Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20
J. Mol. Biol, 2005; 347: 81-93.
Koehler CM, Hwang DK Protein translocation across membranes, Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2005; 11: 287-308.
Curran SP and Koehler CM Mitochondrial biogenesis. Protein import into and across the inner membrane, Topics in Current Genetics: Mitochondrial Function and Biogenesis, 2004; 8: 59-80.
Leuenberger D, Curran SP and Koehler CM Structure, bioenergetics, and biogenesis of mitochondria, The Biogenesis of Cellular Organelles, 2004; 138-163.
Koehler CM Import and assembly, Genetics of Mitochondrial Diseases, 2003; 47-68.
Dyall SD, Lester DC, Schneider RE, Delgadillo-Correa MG, Plumper E, Martinez A, Koehler CM, Johnson PJ Trichomonas vaginalis Hmp35, a putative pore-forming hydrogenosomal membrane protein, can form a complex in yeast mitochondria
J. Biol. Chem, 2003; 278: 30548-30461.
Roesch K, Tranejaerg L, Koehler CM How do defects in mitochondrial protein import lead to deafness, 19th Danavox Symposium: Genetics and the function of the auditory system. , 2002; 19: 139-154.
Komiya T, Rospert S, Koehler CM, Looser R, Schatz G, and Mihara K Interaction of mitochondrial targeting signals with acidic receptor domains along the protein import pathway: Evidence for the “acid chain” hypothesis, EMBO J, 1998; 17: 3886-3898.
Koehler CM, Lindber GL, BrownDR, Beitz DC, Freeman AE, Mayfield JE and Myers AM Replacement of bovine mitochondrial DNA by a sequence variant within a single generation, Genetics, 1991; 129: 247-255.