Posts classified under: Neurobiology

Paul Micevych, Ph.D.


Research efforts in the Micevych laboratory involve understanding the cellular and molecular events underlying estrogen action on neurons and glial cells. Estrogen has profound effects on cognitive function and neuroprotection, as well as, reproductive functions. Estrogen affects the expression and activity of various neuropeptides and sex steroids. In particular they have focused on regulation mu-opioid and nociceptin receptors in the CNS regulation of sexual behavior. Recent experiments have demonstrated the synthesis of progesterone in the brain, its regulation by estrogen and physiologic functions of neuroprogesterone. RT-PCR and calcium imaging experiments in neurons and astrocytes have been used to elucidate the mechanisms of estrogen rapid signaling in both glial cells and neurons. The Micevych laboratory has demonstrated that estrogen can modulate nociceptive signaling through rapid actions on primary sensory neurons demonstrating a novel mechanism of estrogen modulation of pain. Additionally, the Micevych Laboratory has been studying the neuroprotective action of estrogen in the nigrostriatal dopamine system. Estrogen activates the insulin-like growth factor-1 (IGF-1) to ameliorate a hallmark of ParkinsonA?s disease A? the neurodegeneration of dopamine neurons. Significantly, estrogen or IGF-1 is efficacious after either central or peripheral administration. Together these experiments underscore the broad range of estrogen signaling influencing both physiology and pathology.

Mayank Mehta, Ph.D.


A selected list of publications:

Moore Jason J, Ravassard Pascal M, Ho David, Acharya Lavanya, Kees Ashley L, Vuong Cliff, Mehta Mayank R   Dynamics of cortical dendritic membrane potential and spikes in freely behaving rats Science (New York, N.Y.), 2017; 355(6331): .
Acharya Lavanya, Aghajan Zahra M, Vuong Cliff, Moore Jason J, Mehta Mayank R   Causal Influence of Visual Cues on Hippocampal Directional Selectivity Cell, 2016; 164(1-2): 197-207.
Mehta Mayank R   From synaptic plasticity to spatial maps and sequence learning Hippocampus, 2015; 25(6): 756-62.
Aghajan Zahra M, Acharya Lavanya, Moore Jason J, Cushman Jesse D, Vuong Cliff, Mehta Mayank R   Impaired spatial selectivity and intact phase precession in two-dimensional virtual reality Nature neuroscience, 2015; 18(1): 121-8.
Ravassard Pascal, Kees Ashley, Willers Bernard, Ho David, Aharoni Daniel, Cushman Jesse, Aghajan Zahra M, Mehta Mayank R   Multisensory control of hippocampal spatiotemporal selectivity Science (New York, N.Y.), 2013; 340(6138): 1342-6.
Cushman Jesse D, Aharoni Daniel B, Willers Bernard, Ravassard Pascal, Kees Ashley, Vuong Cliff, Popeney Briana, Arisaka Katsushi, Mehta Mayank R   Multisensory control of multimodal behavior: do the legs know what the tongue is doing? PloS one, 2013; 8(11): e80465.
Ghorbani Maryam, Mehta Mayank, Bruinsma Robijn, Levine Alex J   Nonlinear-dynamics theory of up-down transitions in neocortical neural networks Physical review. E, Statistical, nonlinear, and soft matter physics, 2012; 85(2 Pt 1): 021908.
Ahmed Omar J, Mehta Mayank R   Running speed alters the frequency of hippocampal gamma oscillations The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(21): 7373-83.
Hahn Thomas T G, McFarland James M, Berberich Sven, Sakmann Bert, Mehta Mayank R   Spontaneous persistent activity in entorhinal cortex modulates cortico-hippocampal interaction in vivo Nature neuroscience, 2012; 15(11): 1531-8.
Resnik Evgeny, McFarland James M, Sprengel Rolf, Sakmann Bert, Mehta Mayank R   The effects of GluA1 deletion on the hippocampal population code for position The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(26): 8952-68.
Mehta Mayank R   Contribution of Ih to LTP, place cells, and grid cells Cell, 2011; 147(5): 968-70.
McFarland James M, Hahn Thomas T G, Mehta Mayank R   Explicit-duration hidden Markov model inference of UP-DOWN states from continuous signals PloS one, 2011; 6(6): e21606.
Kumar Arvind, Mehta Mayank R   Frequency-Dependent Changes in NMDAR-Dependent Synaptic Plasticity Frontiers in computational neuroscience, 2011; 5(5): 38.
Chen Zhiping, Resnik Evgeny, McFarland James M, Sakmann Bert, Mehta Mayank R   Speed controls the amplitude and timing of the hippocampal gamma rhythm PloS one, 2011; 6(6): e21408.
Ahmed Omar J, Mehta Mayank R   The hippocampal rate code: anatomy, physiology and theory Trends in neurosciences, 2009; 32(6): 329-38.
Mehta Mayank R   Cortico-hippocampal interaction during up-down states and memory consolidation Nature neuroscience, 2007; 10(1): 13-5.
Hahn Thomas T G, Sakmann Bert, Mehta Mayank R   Differential responses of hippocampal subfields to cortical up-down states Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(12): 5169-74.
Hoffman Kari L, Battaglia Francesco P, Harris Kenneth, MacLean Jason N, Marshall Lisa, Mehta Mayank R   The upshot of up states in the neocortex: from slow oscillations to memory formation The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(44): 11838-41.
Hahn Thomas T G, Sakmann Bert, Mehta Mayank R   Phase-locking of hippocampal interneurons’ membrane potential to neocortical up-down states Nature neuroscience, 2006; 9(11): 1359-61.
Mehta Mayank R   Role of rhythms in facilitating short-term memory Neuron, 2005; 45(1): 7-9.
Mehta Mayank R   Cooperative LTP can map memory sequences on dendritic branches Trends in neurosciences, 2004; 27(2): 69-72.
Petersen Carl C H, Hahn Thomas T G, Mehta Mayank, Grinvald Amiram, Sakmann Bert   Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex Proceedings of the National Academy of Sciences of the United States of America, 2003; 100(23): 13638-43.