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Posts classified under: Integrative Center for Addictive Disorders

HomeUCLA Brain Research Institute (BRI)  > People  > Integrative Centers  > Integrative Center for Addictive Disorders
Christopher J. Evans, Ph.D.

Christopher J. Evans, Ph.D.

Biography

Christopher Evans received his Ph.D. from Imperial College London, conducting his thesis research on endorphins and enkephalins, at the Medical Research Council Institute in Mill Hill. After a postdoctoral fellowship at Stanford University, Dr. Evans joined the UCLA faculty in the Department of Psychiatry and Biobehavioral Science. His research accomplishments have included identification of a number of novel endogenous opioid peptides and the cloning of the first opioid receptor. Dr. Evans was Director of the UCLA Brain Research Institute from 2004-2017 and is the Stefan Hatos Professor directing the Shirley and Stefan Hatos Center for Neurophamacology in the UCLA Semel Institute. Dr. Evans is also director of a NIH-funded center – The Center for Opioid Receptors and Drugs of Abuse or CSORDA. CSORDA, with continuous NIH funding for over 30 years. The aims of CSORDA are to understand the action of opioid drugs such as morphine and heroin at the molecular, cellular and behavioral levels.

Publications

View a up-to-date publication list: https://pubmed.ncbi.nlm.nih.gov/collections/48826753/?sort=date

A selected list of publications:

Pradhan Amynah, Smith Monique, McGuire Brenna, Evans Christopher, Walwyn Wendy   Chronic inflammatory injury results in increased coupling of delta opioid receptors to voltage-gated Ca2+ channels Molecular pain, 2013; 9(4): 8.
Williams John T, Ingram Susan L, Henderson Graeme, Chavkin Charles, von Zastrow Mark, Schulz Stefan, Koch Thomas, Evans Christopher J, Christie Macdonald J   Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance Pharmacological reviews, 2013; 65(1): 223-54.
Mittal Nitish, Tan Miao, Egbuta Onyemachi, Desai Nina, Crawford Cynthia, Xie Cui-Wei, Evans Christopher, Walwyn Wendy   Evidence that Behavioral Phenotypes of Morphine in β-arr2-/- Mice Are Due to the Unmasking of JNK Signaling Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012; 10(2): .
Matynia Anna, Parikh Sachin, Chen Bryan, Kim Paul, McNeill David S, Nusinowitz Steven, Evans Christopher, Gorin Michael B   Intrinsically photosensitive retinal ganglion cells are the primary but not exclusive circuit for light aversion Experimental eye research, 2012; 105(23): 60-9.
Pradhan Amynah A, Smith Monique L, Kieffer Brigitte L, Evans Christopher J   Ligand-directed signalling within the opioid receptor family British journal of pharmacology, 2012; 167(5): 960-9.
Piault Elisabeth, Doshi Sameepa, Brandt Barbara A, Angün Colpan, Evans Christopher J, Bergqvist Agneta, Trocio Jeffrey   Linguistic validation of translation of the self-assessment goal achievement (saga) questionnaire from English Health and quality of life outcomes, 2012; 10: 40.
Romero-Calderón Rafael, O’Hare Elizabeth D, Suthana Nanthia A, Scott-Van Zeeland Ashley A, Rizk-Jackson Angela, Attar Aida, Madsen Sarah K, Ghiani Cristina A, Evans Christopher J, Watson Joseph B   Project brainstorm: using neuroscience to connect college students with local schools PLoS biology, 2012; 10(4): e1001310.
Ma Yao-Ying, Cepeda Carlos, Chatta Payush, Franklin Lana, Evans Christopher J, Levine Michael S   Regional and cell-type-specific effects of DAMGO on striatal D1 and D2 dopamine receptor-expressing medium-sized spiny neurons ASN neuro, 2012; 4(2): .
Washburn Lorraine R, Zekzer Dan, Eitan Shoshana, Lu Yuxin, Dang Hoa, Middleton Blake, Evans Christopher J, Tian Jide, Kaufman Daniel L   A potential role for shed soluble major histocompatibility class I molecules as modulators of neurite outgrowth PloS one, 2011; 6(3): e18439.
Lasch Kathryn F, Evans Christopher J, Schatell Dori   A qualitative analysis of patient-reported symptoms of anemia Nephrology nursing journal : journal of the American Nephrology Nurses’ Association, 2011; 36(6): 621-4, 631-2; quiz 633.
Lam Hoa, Maga Matthew, Pradhan Amynah, Evans Christopher J, Maidment Nigel T, Hales Tim G, Walwyn Wendy   Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2 Molecular pain, 2011; 7(8): 24.
Evans Christopher J, Chiou Chiun-Fang, Fitzgerald Kristina A, Evans William J, Ferrell Betty R, Dale William, Fried Linda P, Gandra Shravanthi R, Dennee-Sommers Brooke, Patrick Donald L   Development of a new patient-reported outcome measure in sarcopenia Journal of the American Medical Directors Association, 2011; 12(3): 226-33.
Brubaker Linda, Khullar Vik, Piault Elisabeth, Evans Christopher J, Bavendam Tamara, Beach James, Yeh Yating, Kopp Zoe S, Kelleher Con J, Trocio Jeffrey   Goal attainment scaling in patients with lower urinary tract symptoms: development and pilot testing of the Self-Assessment Goal Achievement (SAGA) questionnaire International urogynecology journal, 2011; 22(8): 937-46.
Ng-Mak Daisy S, Fitzgerald Kristina A, Norquist Josephine M, Banderas Benjamin F, Nelsen Linda M, Evans Christopher J, Healy Cynthia G, Ho Tony W, Bigal Marcelo   Key concepts of migraine postdrome: a qualitative study to develop a post-migraine questionnaire Headache, 2011; 51(1): 105-17.
Poole Daniel P, Pelayo Juan-Carlos, Scherrer Gregory, Evans Christopher J, Kieffer Brigitte L, Bunnett Nigel W   Localization and regulation of fluorescently labeled delta opioid receptor, expressed in enteric neurons of mice Gastroenterology, 2011; 141(3): 982-991.e1-8.
Pradhan Amynah A A, Walwyn Wendy, Nozaki Chihiro, Filliol Dominique, Erbs Eric, Matifas Audrey, Evans Christopher, Kieffer Brigitte L   Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(49): 16459-68.
Escande-Beillard Nathalie, Washburn Lorraine, Zekzer Dan, Wu Zhongqi-Phyllis, Eitan Shoshy, Ivkovic Sonja, Lu Yuxin, Dang Hoa, Middleton Blake, Bilousova Tina V, Yoshimura Yoshitaka, Evans Christopher J, Joyce Sebastian, Tian Jide, Kaufman Daniel L   Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented Journal of immunology (Baltimore, Md. : 1950), 2010; 184(2): 816-23.
Walwyn Wendy M, Miotto Karen A, Evans Christopher J   Opioid pharmaceuticals and addiction: the issues, and research directions seeking solutions Drug and alcohol dependence, 2010; 108(3): 156-65.
Iguchi Martin Y, Evans Christopher J   What neurobiology tells us about addiction Addiction (Abingdon, England), 2010; 105(5): 793-5; discussion 795-6.
Walwyn Wendy, John Scott, Maga Matthew, Evans Christopher J, Hales Tim G   Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons Molecular pharmacology, 2009; 76(1): 134-43.
Hofford Rebecca S, Hodgson Stephen R, Roberts Kris W, Bryant Camron D, Evans Christopher J, Eitan Shoshana   Extracellular signal-regulated kinase activation in the amygdala mediates elevated plus maze behavior during opioid withdrawal Behavioural pharmacology, 2009; 20(7): 576-83.
Yu Y Joy, Arttamangkul Seksiri, Evans Christopher J, Williams John T, von Zastrow Mark   Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(1): 222-33.
Kieffer Brigitte L, Evans Christopher J   Opioid receptors: from binding sites to visible molecules in vivo Neuropharmacology, 2009; 56 Suppl 1(1): 205-12.
Bryant Camron D, Roberts Kristofer W, Culbertson Christopher S, Le Alan, Evans Christopher J, Fanselow Michael S   Pavlovian conditioning of multiple opioid-like responses in mice Drug and alcohol dependence, 2009; 103(1-2): 74-83.
Marquez Paul, Bebawy David, Lelièvre Vincent, Coûté Anne-Claire, Evans Christopher J, Waschek James A, Lutfy Kabirullah   The role of endogenous PACAP in motor stimulation and conditioned place preference induced by morphine in mice Psychopharmacology, 2009; 204(3): 457-63.
Tan Miao, Walwyn Wendy M, Evans Christopher J, Xie Cui-Wei   p38 MAPK and beta-arrestin 2 mediate functional interactions between endogenous micro-opioid and alpha2A-adrenergic receptors in neurons The Journal of biological chemistry, 2009; 284(10): 6270-81.
Piault Elisabeth, Evans Christopher J, Espindle Derek, Kopp Zoe, Brubaker Linda, Abrams Paul   Development and validation of the Overactive Bladder Satisfaction (OAB-S) Questionnaire Neurourology and urodynamics, 2008; 27(3): 179-90.
Wassum Kate M, Evans Christopher J   International Narcotics Research Conference – 39th Annual Meeting IDrugs : the investigational drugs journal, 2008; 11(9): 646-9.
Gioiosa, L.Chen, X.Watkins, R.Klanfer, N.Bryant, C. D.Evans, C. J.Arnold, A. P.   Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice Horm Behav, 2008; 53(1): 124-30.
Parthan Anju, Evans Christopher J, Le Kim   Chronic low back pain: epidemiology, economic burden and patient-reported outcomes in the USA Expert review of pharmacoeconomics & outcomes research, 2006; 6(3): 359-69.
Evans Christopher J, Parthan Anju, Le Kim   Economic and humanistic burden of fibromyalgia in the USA Expert review of pharmacoeconomics & outcomes research, 2006; 6(3): 303-14.
Kho, S. T. Lopez, I. A. Evans, C. Ishiyama, A. Ishiyama, G.   Immunolocalization of orphanin FQ in rat cochlea Brain Res, 2006; 1113(1): 146-52.
Bryant Camron D, Roberts Kristofer W, Byun Janet S, Fanselow Michael S, Evans Christopher J   Morphine analgesic tolerance in 129P3/J and 129S6/SvEv mice Pharmacology, biochemistry, and behavior, 2006; 85(4): 769-79.
Walwyn, W. M. Wei, W. Xie, C. W. Chiu, K. Kieffer, B. L. Evans, C. J. Maidment, N. T.   Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons Neuroscience, 2006; 142(2): 493-503.
Bryant Camron D, Eitan Shoshana, Sinchak Kevin, Fanselow Michael S, Evans Christopher J   NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice American journal of physiology. Regulatory, integrative and comparative physiology, 2006; 291(2): R315-26.
Walwyn Wendy, Maidment Nigel T, Sanders Matthew, Evans Christopher J, Kieffer Brigitte L, Hales Tim G   Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons Molecular pharmacology, 2005; 68(6): 1688-98.
Evans Christopher J, Trudeau Elyse, Mertzanis Polyxane, Marquis Patrick, Peña Beatriz M, Wong Josephine, Mayne Tracy   Development and validation of the Pain Treatment Satisfaction Scale (PTSS): a patient satisfaction questionnaire for use in patients with chronic or acute pain Pain, 2004; 112(3): 254-66.
Walwyn, W. M. Keith, D. E., Jr. Wei, W. Tan, A. M. Xie, C. W. Evans, C. J. Kieffer, B. L. Maidment, N. T.   Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice Neuroscience, 2004; 123(1): 111-21.
Evans Christopher J   Health and work productivity assessment: state of the art or state of flux? Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine, 2004; 46(6 Suppl): S3-11.
Evans Christopher J   Secrets of the opium poppy revealed Neuropharmacology, 2004; 47 Suppl 1(6 Suppl): 293-9.
Eitan, S. Bryant, C. D. Saliminejad, N. Yang, Y. C. Vojdani, E. Keith, D., Jr. Polakiewicz, R. Evans, C. J.   Brain region-specific mechanisms for acute morphine-induced mitogen-activated protein kinase modulation and distinct patterns of activation during analgesic tolerance and locomotor sensitization J Neurosci, 2003; 23(23): 8360-9.
Lutfy, K. Eitan, S. Bryant, C. D. Yang, Y. C. Saliminejad, N. Walwyn, W. Kieffer, B. L. Takeshima, H. Carroll, F. I. Maidment, N. T. Evans, C. J.   Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors J Neurosci, 2003; 23(32): 10331-7.
Charles, A. C. Mostovskaya, N. Asas, K. Evans, C. J. Dankovich, M. L. Hales, T. G.   Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory Mol Pharmacol, 2003; 63(1): 89-95.
Li, Y. Eitan, S. Wu, J. Evans, C. J. Kieffer, B. Sun, X. Polakiewicz, R. D.   Morphine induces desensitization of insulin receptor signaling Mol Cell Biol, 2003; 23(17): 6255-66.
Reeve, J. R., Jr. Keire, D. A. Coskun, T. Green, G. M. Evans, C. Ho, F. J. Lee, T. D. Davis, M. T. Shively, J. E. Solomon, T. E.   Synthesis of biologically active canine CCK-58 Regul Pept, 2003; 113(1-3): 71-7.
Arjomand, J. Cole, S. Evans, C. J.   Novel orphanin FQ/nociceptin transcripts are expressed in human immune cells J Neuroimmunol, 2002; 130(1-2): 100-8.
Kieffer Brigitte L, Evans Christopher J   Opioid tolerance-in search of the holy grail Cell, 2002; 108(5): 587-90.
Zaki, P. A. Keith, D. E., Jr. Thomas, J. B. Carroll, F. I. Evans, C. J.   Agonist-, antagonist-, and inverse agonist-regulated trafficking of the delta-opioid receptor correlates with, but does not require, G protein activation J Pharmacol Exp Ther, 2001; 298(3): 1015-20.
Arjomand, J. Evans, C. J.   Differential splicing of transcripts encoding the orphanin FQ/nociceptin precursor J Neurochem, 2001; 77(3): 720-9.
Ishiyama, A. Ishiyama, G. Baloh, R. W. Evans, C. J.   Heroin-induced reversible profound deafness and vestibular dysfunction Addiction, 2001; 96(9): 1363-4.
Piros, E. T. Charles, R. C. Song, L. Evans, C. J. Hales, T. G.   Cloned delta-opioid receptors in GH(3) cells inhibit spontaneous Ca(2+) oscillations and prolactin release through K(IR) channel activation J Neurophysiol, 2000; 83(5): 2691-8.
Melone, M. Brecha, N. C. Sternini, C. Evans, C. Conti, F.   Etorphine increases the number of mu-opioid receptor-positive cells in the cerebral cortex Neuroscience, 2000; 100(3): 439-43.
Zaki, P. A. Keith, D. E., Jr. Brine, G. A. Carroll, F. I. Evans, C. J.   Ligand-induced changes in surface mu-opioid receptor number: relationship to G protein activation? J Pharmacol Exp Ther, 2000; 292(3): 1127-34.
Rabizadeh, S. Ye, X. Sperandio, S. Wang, J. J. Ellerby, H. M. Ellerby, L. M. Giza, C. Andrusiak, R. L. Frankowski, H. Yaron, Y. Moayeri, N. N. Rovelli, G. Evans, C. J. Butcher, L. L. Nolan, G. P. Assa-Munt, N. Bredesen, D. E.   Neurotrophin dependence domain: a domain required for the mediation of apoptosis by the p75 neurotrophin receptor J Mol Neurosci, 2000; 15(3): 215-29.
Lo, E. H. Pierce, A. R. Matsumoto, K. Kano, T. Evans, C. J. Newcomb, R.   Alterations in K+ evoked profiles of neurotransmitter and neuromodulator amino acids after focal ischemia-reperfusion Neuroscience, 1998; 83(2): 449-58.
Monteillet-Agius, G. Fein, J. Anton, B. Evans, C. J.   ORL-1 and mu opioid receptor antisera label different fibers in areas involved in pain processing J Comp Neurol, 1998; 399(3): 373-83.
Murray, S. R. Evans, C. J. von Zastrow, M.   Phosphorylation is not required for dynamin-dependent endocytosis of a truncated mutant opioid receptor J Biol Chem, 1998; 273(39): 24987-91.
Unterwald, E. M. Anton, B. To, T. Lam, H. Evans, C. J.   Quantitative immunolocalization of mu opioid receptors: regulation by naltrexone Neuroscience, 1998; 85(3): 897-905.
Keith, D. E. Anton, B. Murray, S. R. Zaki, P. A. Chu, P. C. Lissin, D. V. Monteillet-Agius, G. Stewart, P. L. Evans, C. J. von Zastrow, M.   mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain Mol Pharmacol, 1998; 53(3): 377-84.
Rocha, L. L. Evans, C. J. Maidment, N. T.   Amygdala kindling modifies extracellular opioid peptide content in rat hippocampus measured by microdialysis J Neurochem, 1997; 68(2): 616-24.
Yu, T. P. Fein, J. Phan, T. Evans, C. J. Xie, C. W.   Orphanin FQ inhibits synaptic transmission and long-term potentiation in rat hippocampus Hippocampus, 1997; 7(1): 88-94.
Olive, M. F. Anton, B. Micevych, P. Evans, C. J. Maidment, N. T.   Presynaptic versus postsynaptic localization of mu and delta opioid receptors in dorsal and ventral striatopallidal pathways J Neurosci, 1997; 17(19): 7471-9.
Gylys, K. H. Tran, N. Magendzo, K. Zaki, P. Evans, C. J.   cAMP decreases steady-state levels of delta-opioid receptor mRNA in NG108-15 cells Neuroreport, 1997; 8(9-10): 2369-72.
Sternini, C. Spann, M. Anton, B. Keith, D. E., Jr. Bunnett, N. W. von Zastrow, M. Evans, C. Brecha, N. C.   Agonist-selective endocytosis of mu opioid receptor by neurons in vivo Proc Natl Acad Sci U S A, 1996; 93(17): 9241-6.
Anton, B. Fein, J. To, T. Li, X. Silberstein, L. Evans, C. J.   Immunohistochemical localization of ORL-1 in the central nervous system of the rat J Comp Neurol, 1996; 368(2): 229-51.
Zhu, J. Yin, J. Law, P. Y. Claude, P. A. Rice, K. C. Evans, C. J. Chen, C. Yu, L. Liu-Chen, L. Y.   Irreversible binding of cis-(+)-3-methylfentanyl isothiocyanate to the delta opioid receptor and determination of its binding domain J Biol Chem, 1996; 271(3): 1430-4.
Tian, J. Clare-Salzler, M. Herschenfeld, A. Middleton, B. Newman, D. Mueller, R. Arita, S. Evans, C. Atkinson, M. A. Mullen, Y. Sarvetnick, N. Tobin, A. J. Lehmann, P. V. Kaufman, D. L.   Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice Nat Med, 1996; 2(12): 1348-53.
Keith, D. E. Murray, S. R. Zaki, P. A. Chu, P. C. Lissin, D. V. Kang, L. Evans, C. J. von Zastrow, M.   Morphine activates opioid receptors without causing their rapid internalization J Biol Chem, 1996; 271(32): 19021-4.
Keith, D. E., Jr. Evans, C. J.   Mu opioid receptor-like sequences are present throughout vertebrate evolution J Mol Evol, 1996; 43(3): 179-84.
Johnson, J. Chen, T. K. Rickman, D. W. Evans, C. Brecha, N. C.   Multiple gamma-Aminobutyric acid plasma membrane transporters (GAT-1, GAT-2, GAT-3) in the rat retina J Comp Neurol, 1996; 375(2): 212-24.
Li, X. Keith, D. E., Jr. Evans, C. J.   Multiple opioid receptor-like genes are identified in diverse vertebrate phyla FEBS Lett, 1996; 397(1): 25-9.
Rocha, L. Maidment, N. T. Evans, C. J. Ackermann, R. F. Engel, J., Jr.   Opioid peptide release and mu-receptor binding during amygdala kindling in rats: regional discordances Epilepsy Res Suppl, 1996; 12(number): 215-28.
Rocha, L. Briones, M. Ackermann, R. F. Anton, B. Maidment, N. T. Evans, C. J. Engel, J., Jr.   Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems Epilepsy Res, 1996; 26(1): 105-13.
Trapaidze, N. Keith, D. E. Cvejic, S. Evans, C. J. Devi, L. A.   Sequestration of the delta opioid receptor. Role of the C terminus in agonist-mediated internalization J Biol Chem, 1996; 271(46): 29279-85.
Piros, E. T. Prather, P. L. Law, P. Y. Evans, C. J. Hales, T. G.   Voltage-dependent inhibition of Ca2+ channels in GH3 cells by cloned mu- and delta-opioid receptors Mol Pharmacol, 1996; 50(4): 947-56.
Piros, E. T. Prather, P. L. Loh, H. H. Law, P. Y. Evans, C. J. Hales, T. G.   Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells Mol Pharmacol, 1995; 47(5): 1041-9.
Milligan, C. E. Webster, L. Piros, E. T. Evans, C. J. Cunningham, T. J. Levitt, P.   Induction of opioid receptor-mediated macrophage chemotactic activity after neonatal brain injury J Immunol, 1995; 154(12): 6571-81.
Olive, M. F. Bertolucci, M. Evans, C. J. Maidment, N. T.   Microdialysis reveals a morphine-induced increase in pallidal opioid peptide release Neuroreport, 1995; 6(8): 1093-6.
Prather, P. L. McGinn, T. M. Erickson, L. J. Evans, C. J. Loh, H. H. Law, P. Y.   Ability of delta-opioid receptors to interact with multiple G-proteins is independent of receptor density J Biol Chem, 1994; 269(33): 21293-302.
Law, P. Y. McGinn, T. M. Wick, M. J. Erikson, L. J. Evans, C. Loh, H. H.   Analysis of delta-opioid receptor activities stably expressed in CHO cell lines: function of receptor density? J Pharmacol Exp Ther, 1994; 271(3): 1686-94.
Mastrogiacomo, A. Evans, C. J. Gundersen, C. B.   Antipeptide antibodies against a Torpedo cysteine-string protein J Neurochem, 1994; 62(3): 873-80.
Kaufman, D. L. Xia, Y. R. Keith, D. E., Jr. Newman, D. Evans, C. J. Lusis, A. J.   Localization of the delta-opioid receptor gene to mouse chromosome 4 by linkage analysis Genomics, 1994; 19(2): 405-6.
Rocha, L. Maidment, N. T. Evans, C. J. Ackermann, R. F. Engel, J., Jr.   Microdialysis reveals changes in extracellular opioid peptide levels in the amygdala induced by amygdaloid kindling stimulation Exp Neurol, 1994; 126(2): 277-83.
Reeve, J. R., Jr. Eysselein, V. E. Ho, F. J. Chew, P. Vigna, S. R. Liddle, R. A. Evans, C.   Natural and synthetic CCK-58. Novel reagents for studying cholecystokinin physiology Ann N Y Acad Sci, 1994; 713(number): 11-21.
Liu, Y. Schweitzer, E. S. Nirenberg, M. J. Pickel, V. M. Evans, C. J. Edwards, R. H.   Preferential localization of a vesicular monoamine transporter to dense core vesicles in PC12 cells J Cell Biol, 1994; 127(5): 1419-33.
Von Zastrow, M. Keith, D. E., Jr. Evans, C. J.   Agonist-induced state of the delta-opioid receptor that discriminates between opioid peptides and opiate alkaloids Mol Pharmacol, 1993; 44(1): 166-72.
Keith, D. E., Jr. Anton, B. Evans, C. J.   Characterization and mapping of a delta opioid receptor clone from NG108-15 cells Proc West Pharmacol Soc, 1993; 36(number): 299-306.
Ruppert, C. Sandrasagra, A. Anton, B. Evans, C. Schweitzer, E. S. Tobin, A. J.   Rat-1 fibroblasts engineered with GAD65 and GAD67 cDNAs in retroviral vectors produce and release GABA J Neurochem, 1993; 61(2): 768-71.
Evans, C. J. Keith, D. E., Jr. Morrison, H. Magendzo, K. Edwards, R. H.   Cloning of a delta opioid receptor by functional expression Science, 1992; 258(5090): 1952-5.
Madden, J. th Evans, C. J. Tyler, A. N. Esch, F. S. Bohlen, P. Makk, G. Weber, E.   Isolation and characterization of opioid peptides from rabbit cerebellum J Neurochem, 1991; 56(6): 1914-20.
Maidment, N. T. Siddall, B. Rudolph, V. D. Evans, C. J.   Postmortem changes in rat brain extracellular opioid peptides revealed by microdialysis J Neurochem, 1991; 56(6): 1980-4.
Abood, M. E. Eberwine, J. H. Erdelyi, E. Evans, C. J.   Regulation of both preproenkephalin mRNA and its derived opioids by haloperidol–a method for measurement of peptides and mRNA in the same tissue extract Brain Res Mol Brain Res, 1990; 8(3): 243-8.
Tecott, L. H. Rubenstein, J. L. Paxinos, G. Evans, C. J. Eberwine, J. H. Valentino, K. L.   Developmental expression of proenkephalin mRNA and peptides in rat striatum Brain Res Dev Brain Res, 1989; 49(1): 75-86.
Feistner, G. J. Hojrup, P. Evans, C. J. Barofsky, D. F. Faull, K. F. Roepstorff, P.   Mass spectrometric charting of bovine posterior/intermediate pituitary peptides Proc Natl Acad Sci U S A, 1989; 86(16): 6013-7.
Maidment, N. T. Brumbaugh, D. R. Rudolph, V. D. Erdelyi, E. Evans, C. J.   Microdialysis of extracellular endogenous opioid peptides from rat brain in vivo Neuroscience, 1989; 33(3): 549-57.
Stevens, K. E. Leslie, F. M. Evans, C. J. Belluzzi, J. D. Stein, L.   BAM-18: analgesia, hyperalgesia and locomotor effects Neuropeptides, 1988; 12(1): 21-7.
Eberwine, J. H. Barchas, J. D. Hewlett, W. A. Evans, C. J.   Isolation of enzyme cDNA clones by enzyme immunodetection assay: isolation of a peptide acetyltransferase Proc Natl Acad Sci U S A, 1987; 84(5): 1449-53.
Boarder, M. R. Evans, C. Adams, M. Erdelyi, E. Barchas, J. D.   Peptide E and its products, BAM 18 and Leu-enkephalin, in bovine adrenal medulla and cultured chromaffin cells: release in response to stimulation J Neurochem, 1987; 49(6): 1824-32.
Hurlbut, D. E. Evans, C. J. Barchas, J. D. Leslie, F. M.   Pharmacological properties of a proenkephalin A-derived opioid peptide: BAM 18 Eur J Pharmacol, 1987; 138(3): 359-66.
Lorenz, R. G. Tyler, A. N. Faull, K. F. Makk, G. Barchas, J. D. Evans, C. J.   Characterization of endorphins from the pituitary of the spiny dogfish Squalus acanthias Peptides, 1986; 7(1): 119-26.
Bartolome, J. V. Bartolome, M. B. Daltner, L. A. Evans, C. J. Barchas, J. D. Kuhn, C. M. Schanberg, S. M.   Effects of beta-endorphin on ornithine decarboxylase in tissues of developing rats: a potential role for this endogenous neuropeptide in the modulation of tissue growth Life Sci, 1986; 38(25): 2355-62.
Stevens, K. E. Leslie, F. M. Evans, C. J. Barchas, J. D. Belluzzi, J. D. Stein, L.   Intraventricular administration of BAM-18: antinociceptive and locomotor activity in the rat NIDA Res Monogr, 1986; 75(number): 446-9.
Kaldany, R. R. Campanelli, J. T. Makk, G. Evans, C. J. Scheller, R. H.   Proteolytic processing of a peptide precursor in Aplysia neuron R14 J Biol Chem, 1986; 261(13): 5751-7.
Hurlbut, D. E. Evans, C. J. Barchas, J. D. Leslie, F. M.   The pharmacological profile of BAM 18 NIDA Res Monogr, 1986; 75(number): 81-4.
Evans, C. J. Erdelyi, E. Hunter, J. Barchas, J. D.   Co-localization and characterization of immunoreactive peptides derived from two opioid precursors in guinea pig adrenal glands J Neurosci, 1985; 5(12): 3423-7.
Lorenz, R. G. Evans, C. J. Barchas, J. D.   Effects of dehydration on pro-dynorphin derived peptides in the neuro-intermediate lobe of the rat pituitary Life Sci, 1985; 37(16): 1523-8.
Evans, C. J. Barchas, J. D. Esch, F. S. Bohlen, P. Weber, E   Isolation and characterization of an endogenous C-terminal fragment of the alpha-neo-endorphin/dynorphin precursor from bovine caudate nucleus J Neurosci, 1985; 5(7): 1803-7.
Roth, K. A. Makk, G. Beck, O. Faull, K. Tatemoto, K. Evans, C. J. Barchas, J. D.   Isolation and characterization of substance P, substance P 5-11, and substance K from two metastatic ileal carcinoids Regul Pept, 1985; 12(3): 185-99.
Wallace, E. F. Weber, E. Barchas, J. D. Evans, C. J.   A putative processing enzyme from Aplysia that cleaves dynorphin A at the single arginine residue Biochem Biophys Res Commun, 1984; 119(1): 415-22.
Bostwick, D. G. Roth, K. A. Evans, C. J. Barchas, J. D. Bensch, K. G.   Gastrin-releasing peptide, a mammalian analog of bombesin, is present in human neuroendocrine lung tumors Am J Pathol, 1984; 117(2): 195-200.
Roth, K. A. Evans, C. J. Weber, E. Barchas, J. D. Bostwick, D. G. Bensch, K. G.   Gastrin-releasing peptide-related peptides in a human malignant lung carcinoid tumor Cancer Res, 1983; 43(11): 5411-5.
Roth, K. A. Evans, C. J. Lorenz, R. G. Weber, E. Barchas, J. D. Chang, J. K.   Identification of gastrin releasing peptide-related substances in guinea pig and rat brain Biochem Biophys Res Commun, 1983; 112(2): 528-36.
Evans, C. J. Erdelyi, E. Weber, E. Barchas, J. D.   Identification of pro-opiomelanocortin-derived peptides in the human adrenal medulla Science, 1983; 221(4614): 957-60.
Boarder, M. R. Weber, E. Evans, C. J. Erdelyi, E. Barchas, J.   Measurement of total opioid peptides in rat brain and pituitary by radioimmunoassay directed at the alpha-N-acetyl derivative J Neurochem, 1983; 40(16): 1517-22.
Weber, E. Esch, F. S. Bohlen, P. Paterson, S. Corbett, A. D. McKnight, A. T. Kosterlitz, H. W. Barchas, J. D. Evans, C. J.   Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain Proc Natl Acad Sci U S A, 1983; 80(23): 7362-6.
Mues, G. Fuchs, I. Wei, E. T. Weber, E. Evans, C. J. Barchas, J. D. Chang, J. K.   Blood pressure elevation in rats by peripheral administration of Tyr-Gly-Gly-Phe-Met-Arg-Phe and the invertebrate neuropeptide, Phe-Met-Arg-Phe-NH2 Life Sci, 1982; 31(23): 2555-61.
Weber, E. Evans, C. J. Chang, J. K. Barchas, J. D.   Brain distributions of alpha-neo-endorphin and beta-neo-endorphin: evidence for regional processing differences Biochem Biophys Res Commun, 1982; 108(1): 81-8.
Weber, E. Evans, C. J. Barchas, J. D.   Mapping of hypothalamic opioid peptide neurons by a novel immunohistochemical technique: relation to alpha-Neo-endorphin and vasopressin systems Adv Biochem Psychopharmacol, 1982; 33(number): 519-26.
Weber, E. Evans, C. J. Barchas, J. D.   Predominance of the amino-terminal octapeptide fragment of dynorphin in rat brain regions Nature, 1982; 299(5878): 77-9.
Weber, E. Evans, C. J. Barchas, J. D.   Acetylated and nonacetylated forms of beta-endorphin in rat brain and pituitary Biochem Biophys Res Commun, 1981; 103(3): 982-9.
Weber, E.Truscott, R. J.Evans, C.Sullivan, S.Angwin, P.Barchas, J. D.   Alpha-N-acetyl beta-endorphins in the pituitary: immunohistochemical localization using antibodies raised against dynorphin(1-13) J Neurochem, 1981; 36(6): 1977-85.
Evans, C. J. Weber, E. Barchas, J. D.   Isolation and characterization of alpha-N-acetyl beta-endorphin(1-26) from the rat posterior/intermediate pituitary lobe Biochem Biophys Res Commun, 1981; 102(3): 897-904.
Weber, E. Evans, C. J. Samuelsson, S. J. Barchas, J. D.   Novel peptide neuronal system in rat brain and pituitary Science, 1981; 214(4526): 1248-51.
Austen, B. M.Evans, C. J.Smyth, D. G.   Susceptibility of neuroactive peptides to aminopeptidase digestion is related to molecular size Biochem Biophys Res Commun, 1979; 91(4): 1211-7.
Timothy Fong

Timothy Fong, M.D.

Biography

Dr. Fong is a Professor of Psychiatry, board-certified in Addiction Psychiatry, at the Semel Institute for Neuroscience and Human Behavior at UCLA.    

Publications

A selected list of publications:

Fong Timothy W, Reid Rory C, Parhami Iman   Behavioral addictions: where to draw the lines? The Psychiatric clinics of North America, 2012; 35(2): 279-96.
Fink Arlene, Parhami Iman, Rosenthal Richard J, Campos Michael D, Siani Aaron, Fong Timothy W   How Transparent is Behavioral Intervention Research on Pathological Gambling and Other Gambling-Related Disorders? A Systematic Literature Review Addiction (Abingdon, England), 2012; 35(2): .
Parhami Iman, Davtian Margarit, Collard Michael, Lopez Jean, Fong Timothy W   A Preliminary 6-Month Prospective Study Examining Self-reported Religious Preference, Religiosity/Spirituality, and Retention at a Jewish Residential Treatment Center for Substance-Related Disorders The journal of behavioral health services & research, 2012; 35(2): .
Parhami Iman, Siani Aaron, Rosenthal Richard J, Fong Timothy W   Pathological Gambling, Problem Gambling and Sleep Complaints: An Analysis of the National Comorbidity Survey: Replication (NCS-R) Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming, 2012; 35(2): .
Parhami Iman, Hyman Mark, Siani Aaron, Lin Stephanie, Collard Michael, Garcia Johnny, Casaus Laurie, Tsuang John, Fong Timothy W   Screening for addictive disorders within a workers’ compensation clinic: an exploratory study Substance use & misuse, 2012; 47(1): 99-107.
Parhami Iman, Siani Aaron, Rosenthal Richard J, Lin Stephanie, Collard Michael, Fong Timothy W   Sleep and gambling severity in a community sample of gamblers Journal of addictive diseases, 2012; 31(1): 67-79.
Reid Rory C, Carpenter Bruce N, Fong Timothy W   Neuroscience research fails to support claims that excessive pornography consumption causes brain damage Surgical neurology international, 2011; 2(1): 64.
Fong Timothy W, Campos Michael D, Brecht Mary-Lynn, Davis Alice, Marco Adrienne, Pecanha Viviane, Rosenthal Richard J   Problem and pathological gambling in a sample of casino patrons Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming, 2011; 27(1): 35-47.
Xu Jiansong, Azizian Allen, Monterosso John, Domier Catherine P, Brody Arthur L, Fong Timothy W, London Edythe D   Gender effects on mood and cigarette craving during early abstinence and resumption of smoking Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2008; 10(11): 1653-61.
Payer Doris E, Lieberman Matthew D, Monterosso John R, Xu Jiansong, Fong Timothy W, London Edythe D   Differences in cortical activity between methamphetamine-dependent and healthy individuals performing a facial affect matching task Drug and alcohol dependence, 2008; 93(1-2): 93-102.
Fong Timothy W, Tsuang John   Asian-americans, addictions, and barriers to treatment Psychiatry (Edgmont (Pa. : Township)), 2007; 4(11): 51-9.
Fong Timothy W   Understanding and managing compulsive sexual behaviors Psychiatry (Edgmont (Pa. : Township)), 2006; 3(11): 51-8.
Fong Timothy W, De La Garza Richard, Newton Thomas F   A case report of topiramate in the treatment of nonparaphilic sexual addiction Journal of clinical psychopharmacology, 2005; 25(5): 512-4.
Fong Timothy W   Types of psychotherapy for pathological gamblers Psychiatry (Edgmont (Pa. : Township)), 2005; 2(5): 32-9.
Fong Timothy W   The vulnerable faces of pathological gambling Psychiatry (Edgmont (Pa. : Township)), 2005; 2(4): 34-42.
Fong Timothy W   The biopsychosocial consequences of pathological gambling Psychiatry (Edgmont (Pa. : Township)), 2005; 2(3): 22-30.
Tsuang John, Fong Timothy W   Treatment of patients with schizophrenia and substance abuse disorders Current pharmaceutical design, 2004; 10(18): 2249-61.
Michael Fanselow

Michael Fanselow, Ph.D.

Biography

Michael S. Fanselow is a Professor in the Department of Psychology at U.C.L.A. and has held academic appointments at Rennselaer Polytechnic Institute and Dartmouth College before coming to UCLA in 1987. He received his Ph.D. from the University of Washington and received the Edwin B Newman Award for Excellence in Research for his dissertation work there. He has also received the Early Career Distinguished Scientific Contribution Award and the D. O. Hebb Award from the American Psychological Association and the Troland Award from the National Academy of Science. He was elected President of the American Psychological Association’s Division of Behavioral Neuroscience and Comparative Psychology and President of the Pavlovian Society. He currently holds positions as the Staglin Family Chair and the Director of the Staglin Music Festival Center for Brain & Behavioral Health.

Publications

A selected list of publications:

Zelikowsky Moriel, Pham Daniel L, Fanselow Michael S   Temporal factors control hippocampal contributions to fear renewal after extinction Hippocampus, 2012; 22(5): 1096-106.
Zelikowsky Moriel, Bissiere Stephanie, Fanselow Michael S   Contextual fear memories formed in the absence of the dorsal hippocampus decay across time The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(10): 3393-7.
Nakashiba Toshiaki, Cushman Jesse D, Pelkey Kenneth A, Renaudineau Sophie, Buhl Derek L, McHugh Thomas J, Rodriguez Barrera Vanessa, Chittajallu Ramesh, Iwamoto Keisuke S, McBain Chris J, Fanselow Michael S, Tonegawa Susumu   Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion Cell, 2012; 149(1): 188-201.
Reger Maxine L, Poulos Andrew M, Buen Floyd, Giza Christopher C, Hovda David A, Fanselow Michael S   Concussive brain injury enhances fear learning and excitatory processes in the amygdala Biological psychiatry, 2012; 71(4): 335-43.
Eadie Brennan D, Cushman Jesse, Kannangara Timal S, Fanselow Michael S, Christie Brian R   NMDA receptor hypofunction in the dentate gyrus and impaired context discrimination in adult Fmr1 knockout mice Hippocampus, 2012; 22(2): 241-54.
Cushman Jesse D, Maldonado Jose, Kwon Eunice E, Garcia A Denise, Fan Guoping, Imura Tetsuya, Sofroniew Michael V, Fanselow Michael S   Juvenile neurogenesis makes essential contributions to adult brain structure and plays a sex-dependent role in fear memories Frontiers in behavioral neuroscience, 2012; 6(2): 3.
Halladay Lindsay R, Zelikowsky Moriel, Blair Hugh T, Fanselow Michael S   Reinstatement of extinguished fear by an unextinguished conditional stimulus Frontiers in behavioral neuroscience, 2012; 6(2): 18.
Long Virginia A, Fanselow Michael S   Stress-enhanced fear learning in rats is resistant to the effects of immediate massed extinction Stress (Amsterdam, Netherlands), 2012; 22(2): .
Cushman Jesse D, Moore Melissa D, Jacobs Nate S, Olsen Richard W, Fanselow Michael S   Behavioral pharmacogenetic analysis on the role of the α4 GABA(A) receptor subunit in the ethanol-mediated impairment of hippocampus-dependent contextual learning Alcoholism, clinical and experimental research, 2011; 35(11): 1948-59.
Rau Vinuta, Oh Irene, Liao Mark, Bodarky Christina, Fanselow Michael S, Homanics Gregg E, Sonner James M, Eger Edmond I   Gamma-aminobutyric acid type A receptor β3 subunit forebrain-specific knockout mice are resistant to the amnestic effect of isoflurane Anesthesia and analgesia, 2011; 113(3): 500-4.
Krasne Franklin B, Fanselow Michael S, Zelikowsky Moriel   Design of a neurally plausible model of fear learning Frontiers in behavioral neuroscience, 2011; 5(6013): 41.
Bissiere Stephanie, Zelikowsky Moriel, Ponnusamy Ravikumar, Jacobs Nathan S, Blair Hugh T, Fanselow Michael S   Electrical synapses control hippocampal contributions to fear learning and memory Science (New York, N.Y.), 2011; 331(6013): 87-91.
Wiltgen Brian J, Royle Gordon A, Gray Erin E, Abdipranoto Andrea, Thangthaeng Nopporn, Jacobs Nate, Saab Faysal, Tonegawa Susumu, Heinemann Stephen F, O’Dell Thomas J, Fanselow Michael S, Vissel Bryce   A role for calcium-permeable AMPA receptors in synaptic plasticity and learning PloS one, 2010; 5(9): .
Haubensak Wulf, Kunwar Prabhat S, Cai Haijiang, Ciocchi Stephane, Wall Nicholas R, Ponnusamy Ravikumar, Biag Jonathan, Dong Hong-Wei, Deisseroth Karl, Callaway Edward M, Fanselow Michael S, Lüthi Andreas, Anderson David J   Genetic dissection of an amygdala microcircuit that gates conditioned fear Nature, 2010; 468(7321): 270-6.
Cibelli Mario, Fidalgo Antonio Rei, Terrando Niccolò, Ma Daqing, Monaco Claudia, Feldmann Marc, Takata Masao, Lever Isobel J, Nanchahal Jagdeep, Fanselow Michael S, Maze Mervyn   Role of interleukin-1beta in postoperative cognitive dysfunction Annals of neurology, 2010; 68(3): 360-8.
Poulos Andrew M, Ponnusamy Ravikumar, Dong Hong-Wei, Fanselow Michael S   Compensation in the neural circuitry of fear conditioning awakens learning circuits in the bed nuclei of the stria terminalis Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(33): 14881-6.
Zelikowsky Moriel, Fanselow Michael S   Opioid regulation of Pavlovian overshadowing in fear conditioning Behavioral neuroscience, 2010; 124(4): 510-9.
Jacobs Nathan S, Cushman Jesse D, Fanselow Michael S   The accurate measurement of fear memory in Pavlovian conditioning: Resolving the baseline issue Journal of neuroscience methods, 2010; 190(2): 235-9.
Ponomarev Igor, Rau Vinuta, Eger Edmond I, Harris R Adron, Fanselow Michael S   Amygdala transcriptome and cellular mechanisms underlying stress-enhanced fear learning in a rat model of posttraumatic stress disorder Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010; 35(6): 1402-11.
Fanselow Michael S, Dong Hong-Wei   Are the dorsal and ventral hippocampus functionally distinct structures? Neuron, 2010; 65(1): 7-19.
Fanselow Michael S   From contextual fear to a dynamic view of memory systems Trends in cognitive sciences, 2010; 14(1): 7-15.
Rau Vinuta, Iyer Sangeetha V, Oh Irene, Chandra Dev, Harrison Neil, Eger Edmond I, Fanselow Michael S, Homanics Gregg E, Sonner James M   Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane Anesthesia and analgesia, 2009; 109(6): 1816-22.
Dong Hong-Wei, Swanson Larry W, Chen Lin, Fanselow Michael S, Toga Arthur W   Genomic-anatomic evidence for distinct functional domains in hippocampal field CA1 Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(28): 11794-9.
Bryant Camron D, Roberts Kristofer W, Culbertson Christopher S, Le Alan, Evans Christopher J, Fanselow Michael S   Pavlovian conditioning of multiple opioid-like responses in mice Drug and alcohol dependence, 2009; 103(1-2): 74-83.
Poulos Andrew M, Li Veronica, Sterlace Sarah S, Tokushige Fonda, Ponnusamy Ravikumar, Fanselow Michael S   Persistence of fear memory across time requires the basolateral amygdala complex Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(28): 11737-41.
Quinn Jennifer J, Wied Heather M, Liu Dorothy, Fanselow Michael S   Post-training excitotoxic lesions of the dorsal hippocampus attenuate generalization in auditory delay fear conditioning The European journal of neuroscience, 2009; 29(8): 1692-700.
Rau Vinuta, Fanselow Michael S   Exposure to a stressor produces a long lasting enhancement of fear learning in rats Stress (Amsterdam, Netherlands), 2009; 12(2): 125-33.
Rau Vinuta, Oh Irene, Laster Michael, Eger Edmond I, Fanselow Michael S   Isoflurane suppresses stress-enhanced fear learning in a rodent model of post-traumatic stress disorder Anesthesiology, 2009; 110(3): 487-95.
Wiltgen Brian J, Godsil Bill P, Peng Zechun, Saab Faysal, June Harry L, Linn Michael L Van, Cook James M, Houser Carolyn R, O’Dell Tom J, Homanics Gregg E, Fanselow Michael S   The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala Frontiers in behavioral neuroscience, 2009; 3(2): 37.
Bryant Camron D, Zhang Nanci N, Sokoloff Greta, Fanselow Michael S, Ennes Helena S, Palmer Abraham A, McRoberts James A   Behavioral differences among C57BL/6 substrains: implications for transgenic and knockout studies Journal of neurogenetics, 2008; 22(4): 315-31.
Quinn Jennifer J, Wied Heather M, Ma Quang D, Tinsley Matthew R, Fanselow Michael S   Dorsal hippocampus involvement in delay fear conditioning depends upon the strength of the tone-footshock association Hippocampus, 2008; 18(7): 640-54.
Quinn Jennifer J, Ma Quang D, Tinsley Matthew R, Koch Christof, Fanselow Michael S   Inverse temporal contributions of the dorsal hippocampus and medial prefrontal cortex to the expression of long-term fear memories Learning & memory (Cold Spring Harbor, N.Y.), 2008; 15(5): 368-72.
Matynia Anna, Anagnostaras Stephan G, Wiltgen Brian J, Lacuesta Maress, Fanselow Michael S, Silva Alcino J   A high through-put reverse genetic screen identifies two genes involved in remote memory in mice PloS one, 2008; 3(5): e2121.
Hunt Pamela S, Fanselow Michael S, Richardson Rick, Mauk Michael D, Freeman John H, Stanton Mark E   Synapses, circuits, and the ontogeny of learning Developmental psychobiology, 2007; 49(7): 649-63.
McHugh Thomas J, Jones Matthew W, Quinn Jennifer J, Balthasar Nina, Coppari Roberto, Elmquist Joel K, Lowell Bradford B, Fanselow Michael S, Wilson Matthew A, Tonegawa Susumu   Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network Science (New York, N.Y.), 2007; 317(5834): 94-9.
de Oca Beatrice M, Minor Thomas R, Fanselow Michael S   Brief flight to a familiar enclosure in response to a conditional stimulus in rats The Journal of general psychology, 2007; 134(2): 153-72.
Sonner James M, Werner David F, Elsen Frank P, Xing Yilei, Liao Mark, Harris R Adron, Harrison Neil L, Fanselow Michael S, Eger Edmond I, Homanics Gregg E   Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane Anesthesiology, 2007; 106(1): 107-13.
Blaeser Frank, Sanders Matthew J, Truong Nga, Ko Shanelle, Wu Long Jun, Wozniak David F, Fanselow Michael S, Zhuo Min, Chatila Talal A   Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient mice Molecular and cellular biology, 2006; 26(23): 9105-15.
Bryant Camron D, Roberts Kristofer W, Byun Janet S, Fanselow Michael S, Evans Christopher J   Morphine analgesic tolerance in 129P3/J and 129S6/SvEv mice Pharmacology, biochemistry, and behavior, 2006; 85(4): 769-79.
Landeira-Fernandez J, DeCola Joseph P, Kim Jeansok J, Fanselow Michael S   Immediate shock deficit in fear conditioning: effects of shock manipulations Behavioral neuroscience, 2006; 120(4): 873-9.
Bryant Camron D, Eitan Shoshana, Sinchak Kevin, Fanselow Michael S, Evans Christopher J   NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice American journal of physiology. Regulatory, integrative and comparative physiology, 2006; 291(2): R315-26.
Wiltgen Brian J, Sanders Matthew J, Anagnostaras Stephan G, Sage Jennifer R, Fanselow Michael S   Context fear learning in the absence of the hippocampus The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006; 26(20): 5484-91.
Godsil Bill P, Stefanacci Lisa, Fanselow Michael S   Bright light suppresses hyperactivity induced by excitotoxic dorsal hippocampus lesions in the rat Behavioral neuroscience, 2005; 119(5): 1339-52.
Schwetz Ines, McRoberts James A, Coutinho Santosh V, Bradesi Sylvie, Gale Greg, Fanselow Michael, Million Mulugeta, Ohning Gordon, Taché Yvette, Plotsky Paul M, Mayer Emeran A   Corticotropin-releasing factor receptor 1 mediates acute and delayed stress-induced visceral hyperalgesia in maternally separated Long-Evans rats American journal of physiology. Gastrointestinal and liver physiology, 2005; 289(4): G704-12.
Chowdhury Najwa, Quinn Jennifer J, Fanselow Michael S   Dorsal hippocampus involvement in trace fear conditioning with long, but not short, trace intervals in mice Behavioral neuroscience, 2005; 119(5): 1396-402.
Sonner James M, Cascio Mike, Xing Yilei, Fanselow Michael S, Kralic Jason E, Morrow A Leslie, Korpi Esa R, Hardy Steven, Sloat Brian, Eger Edmond I, Homanics Gregg E   Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear Molecular pharmacology, 2005; 68(1): 61-8.
Sanders Matthew J, Kieffer Brigitte L, Fanselow Michael S   Deletion of the mu opioid receptor results in impaired acquisition of Pavlovian context fear Neurobiology of learning and memory, 2005; 84(1): 33-41.
Bradesi Sylvie, Schwetz Ines, Ennes Helena S, Lamy Christophe M R, Ohning Gordon, Fanselow Michael, Pothoulakis Charalabos, McRoberts James A, Mayer Emeran A   Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia American journal of physiology. Gastrointestinal and liver physiology, 2005; 289(1): G42-53.
Sonner James M, Vissel Bryce, Royle Gordon, Maurer Anya, Gong Diane, Baron Nicole V, Harrison Neil, Fanselow Michael, Eger Edmond I   The effect of three inhaled anesthetics in mice harboring mutations in the GluR6 (kainate) receptor gene Anesthesia and analgesia, 2005; 101(1): 143-8, table of contents.
Fendt Markus, Fanselow Michael S, Koch Michael   Lesions of the dorsal hippocampus block trace fear conditioned potentiation of startle Behavioral neuroscience, 2005; 119(3): 834-8.
Sonner James M, Xing Yilei, Zhang Yi, Maurer Anya, Fanselow Michael S, Dutton Robert C, Eger Edmond I   Administration of epinephrine does not increase learning of fear to tone in rats anesthetized with isoflurane or desflurane Anesthesia and analgesia, 2005; 100(5): 1333-7, table of contents.
de Oca Beatrice M, Fanselow Michael S   Amygdala and periaqueductal gray lesions only partially attenuate unconditional defensive responses in rats exposed to a cat Integrative physiological and behavioral science : the official journal of the Pavlovian Society, 2005; 39(4): 318-33.
Quinn Jennifer J, Loya Fred, Ma Quang D, Fanselow Michael S   Dorsal hippocampus NMDA receptors differentially mediate trace and contextual fear conditioning Hippocampus, 2005; 15(5): 665-74.
Rau Vinuta, DeCola Joseph P, Fanselow Michael S   Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder Neuroscience and biobehavioral reviews, 2005; 29(8): 1207-23.
Fanselow Michael S, Poulos Andrew M   The neuroscience of mammalian associative learning Annual review of psychology, 2005; 56(3): 207-34.
Wiltgen Brian J, Sanders Matthew J, Ferguson Carolyn, Homanics Gregg E, Fanselow Michael S   Trace fear conditioning is enhanced in mice lacking the delta subunit of the GABAA receptor Learning & memory (Cold Spring Harbor, N.Y.), 2005; 12(3): 327-33.
Godsil Bill P, Fanselow Michael S   Light stimulus change evokes an activity response in the rat Learning & behavior : a Psychonomic Society publication, 2004; 32(3): 299-310.
Gale Greg D, Anagnostaras Stephan G, Godsil Bill P, Mitchell Shawn, Nozawa Takashi, Sage Jennifer R, Wiltgen Brian, Fanselow Michael S   Role of the basolateral amygdala in the storage of fear memories across the adult lifetime of rats The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004; 24(15): 3810-5.
Stote Deborah L, Fanselow Michael S   NMDA receptor modulation of incidental learning in Pavlovian context conditioning Behavioral neuroscience, 2004; 118(1): 253-7.
Tinsley Matthew R, Quinn Jennifer J, Fanselow Michael S   The role of muscarinic and nicotinic cholinergic neurotransmission in aversive conditioning: comparing pavlovian fear conditioning and inhibitory avoidance Learning & memory (Cold Spring Harbor, N.Y.), 2004; 11(1): 35-42.
Mayer Emeran A, Fanselow Michael S   Dissecting the components of the central response to stress Nature neuroscience, 2003; 6(10): 1011-2.
Meffert Mollie K, Chang Jolene M, Wiltgen Brian J, Fanselow Michael S, Baltimore David   NF-kappa B functions in synaptic signaling and behavior Nature neuroscience, 2003; 6(10): 1072-8.
Han C J, O’Tuathaigh Colm M, van Trigt Laurent, Quinn Jennifer J, Fanselow Michael S, Mongeau Raymond, Koch Christof, Anderson David J   Trace but not delay fear conditioning requires attention and the anterior cingulate cortex Proceedings of the National Academy of Sciences of the United States of America, 2003; 100(22): 13087-92.
Sanders Matthew J, Fanselow Michael S   Pre-training prevents context fear conditioning deficits produced by hippocampal NMDA receptor blockade Neurobiology of learning and memory, 2003; 80(2): 123-9.
Eger Edmond I, Xing Yilei, Pearce Robert, Shafer Steven, Laster Michael J, Zhang Yi, Fanselow Michael S, Sonner James M   Isoflurane antagonizes the capacity of flurothyl or 1,2-dichlorohexafluorocyclobutane to impair fear conditioning to context and tone Anesthesia and analgesia, 2003; 96(4): 1010-8, table of contents.
Fanselow Michael S, Gale Greg D   The amygdala, fear, and memory Annals of the New York Academy of Sciences, 2003; 985(4): 125-34.
Sanders Matthew J, Wiltgen Brian J, Fanselow Michael S   The place of the hippocampus in fear conditioning European journal of pharmacology, 2003; 463(1-3): 217-23.
González Felisa, Quinn Jennifer J, Fanselow Michael S   Differential effects of adding and removing components of a context on the generalization of conditional freezing Journal of experimental psychology. Animal behavior processes, 2003; 29(1): 78-83.
Dutton Robert C, Maurer Anya J, Sonner James M, Fanselow Michael S, Laster Michael J, Eger Edmond I   Isoflurane causes anterograde but not retrograde amnesia for pavlovian fear conditioning Anesthesiology, 2002; 96(5): 1223-9.
Quinn Jennifer J, Oommen Santosh S, Morrison Glenn E, Fanselow Michael S   Post-training excitotoxic lesions of the dorsal hippocampus attenuate forward trace, backward trace, and delay fear conditioning in a temporally specific manner Hippocampus, 2002; 12(4): 495-504.
Dutton Robert C, Maurer Anya J, Sonner James M, Fanselow Michael S, Laster Michael J, Eger Edmond I   Short-term memory resists the depressant effect of the nonimmobilizer 1-2-dichlorohexafluorocyclobutane (2N) more than long-term memory Anesthesia and analgesia, 2002; 94(3): 631-9; table of contents.
Anagnostaras Stephan G, Gale Greg D, Fanselow Michael S   The hippocampus and Pavlovian fear conditioning: reply to Bast et al Hippocampus, 2002; 12(4): 561-5.
Alicia Izquierdo, Ph.D.

Alicia Izquierdo, Ph.D.

Publications

A selected list of publications:

Hart Evan E, Blair Garrett J, O’Dell Thomas J, Blair Hugh T, Izquierdo Alicia   Chemogenetic Modulation and Single-Photon Calcium Imaging in Anterior Cingulate Cortex Reveal a Mechanism for Effort-Based Decisions The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020; 40(29): 5628-5643.
Aguirre Claudia G, Stolyarova Alexandra, Das Kanak, Kolli Saisriya, Marty Vincent, Ray Lara, Spigelman Igor, Izquierdo Alicia   Sex-dependent effects of chronic intermittent voluntary alcohol consumption on attentional, not motivational, measures during probabilistic learning and reversal PloS one, 2020; 15(6): e0234729.
Stolyarova A, Rakhshan M, Hart E E, O’Dell T J, Peters M A K, Lau H, Soltani A, Izquierdo A   Contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty Nature communications, 2019; 10(1): 4704.
Soltani Alireza, Izquierdo Alicia   Adaptive learning under expected and unexpected uncertainty Nature reviews. Neuroscience, 2019; .
Izquierdo Alicia, Aguirre Claudia, Hart Evan E, Stolyarova Alexandra   Rodent Models of Adaptive Value Learning and Decision-Making Methods in molecular biology (Clifton, N.J.), 2019; 2011: 105-119.
Hart Evan E, Izquierdo Alicia   Quantity versus quality: Convergent findings in effort-based choice tasks Behavioural processes, 2019; 164: 178-185.
Izquierdo Alicia   Functional Heterogeneity within Rat Orbitofrontal Cortex in Reward Learning and Decision Making The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017; 37(44): 10529-10540.
Hart Evan E, Gerson Julian O, Zoken Yael, Garcia Marisella, Izquierdo Alicia   Anterior cingulate cortex supports effort allocation toward a qualitatively preferred option The European journal of neuroscience, 2017; .
Thompson Andrew B, Gerson Julian, Stolyarova Alexandra, Bugarin Amador, Hart Evan E, Jentsch J David, Izquierdo Alicia   Steep effort discounting of a preferred reward over a freely-available option in prolonged methamphetamine withdrawal in male rats Psychopharmacology, 2017; .
Hart Evan E, Izquierdo Alicia   Basolateral amygdala supports the maintenance of value and effortful choice of a preferred option The European journal of neuroscience, 2016; .
Izquierdo Alicia, Silva Alcino J   Hijacking translation in addiction eLife, 2016; 5: .
Hart Evan E, Stolyarova Alexandra, Conoscenti Michael A, Minor Thomas R, Izquierdo Alicia   Rigid patterns of effortful choice behavior after acute stress in rats Stress (Amsterdam, Netherlands), 2016; 1-10.
Izquierdo Alicia, Pozos Hilda, Torre Adrianna De La, DeShields Simone, Cevallos James, Rodriguez Jonathan, Stolyarova Alexandra   Sex differences, learning flexibility, and striatal dopamine D1 and D2 following adolescent drug exposure in rats Behavioural brain research, 2016; .
Izquierdo A, Brigman J L, Radke A K, Rudebeck P H, Holmes A   The neural basis of reversal learning: An updated perspective Neuroscience, 2016; .
Stolyarova Alexandra, Izquierdo Alicia   Distinct patterns of outcome valuation and amygdala-prefrontal cortex synaptic remodeling in adolescence and adulthood Frontiers in behavioral neuroscience, 2015; 9: 115.
Thompson Andrew B, Stolyarova Alexandra, Ying Zhe, Zhuang Yumei, Gomez-Pinilla Fernando, Izquierdo Alicia   Methamphetamine blocks exercise effects on Bdnf and Drd2 gene expression in frontal cortex and striatum Neuropharmacology, 2015; .
Ochoa Jesus G, Stolyarova Alexandra, Kaur Amandeep, Hart Evan E, Bugarin Amador, Izquierdo Alicia   Post-training depletions of basolateral amygdala serotonin fail to disrupt discrimination, retention, or reversal learning Frontiers in neuroscience, 2015; 9: 155.
Wassum Kate M, Izquierdo Alicia   The basolateral amygdala in reward learning and addiction Neuroscience and biobehavioral reviews, 2015; .
Ye Tony, Pozos Hilda, Phillips Tamara J, Izquierdo Alicia   Long-term effects of exposure to methamphetamine in adolescent rats Drug and alcohol dependence, 2014; .
Stolyarova Alexandra, O’Dell Steve J, Marshall John F, Izquierdo Alicia   Positive and negative feedback learning and associated dopamine and serotonin transporter binding after methamphetamine Behavioural brain research, 2014; .
Stolyarova Alexandra, Thompson Andrew B, Barrientos Ruth M, Izquierdo Alicia   Reductions in Frontocortical Cytokine Levels are Associated with Long-Lasting Alterations in Reward Valuation after Methamphetamine Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014; .
Izquierdo Alicia, Darling Chelsi, Manos Nic, Pozos Hilda, Kim Charissa, Ostrander Serena, Cazares Victor, Stepp Haley, Rudebeck Peter H   Basolateral amygdala lesions facilitate reward choices after negative feedback in rats The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(9): 4105-9.
Kosheleff Alisa R, Rodriguez Danilo, O’Dell Steve J, Marshall John F, Izquierdo Alicia   Comparison of single-dose and extended methamphetamine administration on reversal learning in rats Psychopharmacology, 2012; 224(3): 459-67.
Barkus Chris, Feyder Michael, Graybeal Carolyn, Wright Tara, Wiedholz Lisa, Izquierdo Alicia, Kiselycznyk Carly, Schmitt Wolfram, Sanderson David J, Rawlins J Nicholas P, Saksida Lisa M, Bussey Timothy J, Sprengel Rolf, Bannerman David, Holmes Andrew   Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder? Neuropharmacology, 2012; 62(3): 1263-72.
Izquierdo Alicia, Carlos Kathleen, Ostrander Serena, Rodriguez Danilo, McCall-Craddolph Aaron, Yagnik Gargey, Zhou Feimeng   Impaired reward learning and intact motivation after serotonin depletion in rats Behavioural brain research, 2012; 233(2): 494-9.
Izquierdo Alicia, Jentsch J David   Reversal learning as a measure of impulsive and compulsive behavior in addictions Psychopharmacology, 2012; 219(2): 607-20.
Izquierdo Alicia, Belcher Annabelle M   Rodent models of adaptive decision making Methods in molecular biology (Clifton, N.J.), 2012; 829(3): 85-101.
Kosheleff Alisa R, Grimes Millie, O’Dell Steve J, Marshall John F, Izquierdo Alicia   Work aversion and associated changes in dopamine and serotonin transporter after methamphetamine exposure in rats Psychopharmacology, 2012; 219(2): 411-20.
Ostrander Serena, Cazares Victor A, Kim Charissa, Cheung Shauna, Gonzalez Isabel, Izquierdo Alicia   Orbitofrontal cortex and basolateral amygdala lesions result in suboptimal and dissociable reward choices on cue-guided effort in rats Behavioral neuroscience, 2011; 125(3): 350-9.
Izquierdo Alicia, Murray Elisabeth A   Functional interaction of medial mediodorsal thalamic nucleus but not nucleus accumbens with amygdala and orbital prefrontal cortex is essential for adaptive response selection after reinforcer devaluation The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(2): 661-9.
Brigman Jonathan L, Mathur Poonam, Harvey-White Judith, Izquierdo Alicia, Saksida Lisa M, Bussey Timothy J, Fox Stephanie, Deneris Evan, Murphy Dennis L, Holmes Andrew   Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice Cerebral cortex (New York, N.Y. : 1991), 2010; 20(8): 1955-63.
Izquierdo Alicia, Belcher Annabelle M, Scott Lori, Cazares Victor A, Chen Jack, O’Dell Steven J, Malvaez Melissa, Wu Tiffany, Marshall John F   Reversal-specific learning impairments after a binge regimen of methamphetamine in rats: possible involvement of striatal dopamine Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010; 35(2): 505-14.
Chudasama Yogita, Izquierdo Alicia, Murray Elisabeth A   Distinct contributions of the amygdala and hippocampus to fear expression The European journal of neuroscience, 2009; 30(12): 2327-37.
Izquierdo Alicia, Newman Timothy K, Higley J Dee, Murray Elisabeth A   Genetic modulation of cognitive flexibility and socioemotional behavior in rhesus monkeys Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(35): 14128-33.
Wellman C L, Izquierdo A, Garrett J E, Martin K P, Carroll J, Millstein R, Lesch K-P, Murphy D L, Holmes A   Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(3): 684-91.
Murray Elisabeth A, Izquierdo Alicia   Orbitofrontal cortex and amygdala contributions to affect and action in primates Annals of the New York Academy of Sciences, 2007; 1121(8): 273-96.
Izquierdo Alicia, Murray Elisabeth A   Selective bilateral amygdala lesions in rhesus monkeys fail to disrupt object reversal learning The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(5): 1054-62.
Izquierdo Alicia, Wellman Cara L, Holmes Andrew   Brief uncontrollable stress causes dendritic retraction in infralimbic cortex and resistance to fear extinction in mice The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006; 26(21): 5733-8.
Izquierdo Alicia, Wiedholz Lisa M, Millstein Rachel A, Yang Rebecca J, Bussey Timothy J, Saksida Lisa M, Holmes Andrew   Genetic and dopaminergic modulation of reversal learning in a touchscreen-based operant procedure for mice Behavioural brain research, 2006; 171(2): 181-8.
Izquierdo Alicia, Suda Robin K, Murray Elisabeth A   Comparison of the effects of bilateral orbital prefrontal cortex lesions and amygdala lesions on emotional responses in rhesus monkeys The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005; 25(37): 8534-42.
Izquierdo Alicia, Murray Elisabeth A   Opposing effects of amygdala and orbital prefrontal cortex lesions on the extinction of instrumental responding in macaque monkeys The European journal of neuroscience, 2005; 22(9): 2341-6.
Izquierdo Alicia, Suda Robin K, Murray Elisabeth A   Bilateral orbital prefrontal cortex lesions in rhesus monkeys disrupt choices guided by both reward value and reward contingency The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004; 24(34): 7540-8.
Izquierdo Alicia, Murray Elisabeth A   Combined unilateral lesions of the amygdala and orbital prefrontal cortex impair affective processing in rhesus monkeys Journal of neurophysiology, 2004; 91(5): 2023-39.
Baxter M G, Parker A, Lindner C C, Izquierdo A D, Murray E A   Control of response selection by reinforcer value requires interaction of amygdala and orbital prefrontal cortex The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000; 20(11): 4311-9.
Boothe R G, Louden T, Aiyer A, Izquierdo A, Drews C, Lambert S R   Visual outcome after contact lens and intraocular lens correction of neonatal monocular aphakia in monkeys Investigative ophthalmology & visual science, 2000; 41(1): 110-9.
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