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HomeUCLA Brain Research Institute (BRI)  > People  > Integrative Centers  > Integrative Center for Addictive Disorders

Gina Poe, Ph.D.

Biography

Gina Poe has been working since 1995 on the mechanisms through which sleep serves memory consolidation and restructuring. Dr. Poe is a southern California native who graduated from Stanford University then worked for two post-baccalaureate years at the VA researching Air Force Test Pilots’ brainwave signatures under high-G maneuvers. She then earned her PhD in Basic Sleep in the Neuroscience Interdepartmental Program at UCLA under the guidance of Ronald Harper then moved to the University of Arizona for her postdoctoral studies with Carol Barnes and Bruce McNaughtons looking at graceful degradation of hippocampal function in aged rats as well as hippocampal coding in a 3-D maze navigated in the 1998 space shuttle mission. She brought these multiunit teachings to answer a burning question of whether REM sleep were for remembering or forgetting and found that activity of neurons during REM sleep is consistent both with the consolidation of novel memories and the elimination of already consolidated memories from the hippocampus, readying the associative memory network for new learning the next day. Moving first to Washington State University then to the University of Michigan before joining UCLA in 2016, Poe has over 80 undergraduates, 9 graduate students, and 8 postdoctoral scholars, and has served in university faculty governance as well as led 5 different programs designed to diversify the neuroscience workforce and increase representation of people of the global majority in the STEM fields. At UCLA she continues research and teaching and Directs the COMPASS-Life Sciences and BRI-SURE programs and co-Directs the MARC-U*STAR program. Nationally she has served as course director of the Marine Biological Lab’s SPINES course and co-Directs the Society for Neuroscience’s NSP program which earned the nation’s highest mentoring honor in 2018. These programs have over 1000 PhD level alumni.

Research Interests

The Poe lab investigates the mechanisms by which sleep traits serve learning and memory consolidation. Memories are encoded by the pattern of synaptic connections between neurons. We employ tetrode recording and optogenetic techniques in learning animals to see how neural patterns underlying learning are reactivated during sleep, and how activity during sleep influences the neural memory code. Both strengthening and weakening of synapses is important to the process of sculpting a network when we make new memories and integrate them into old schema. Results from our studies suggest that while synaptic strengthening can be efficiently accomplished during the waking learning process, the synaptic weakening part of memory integration requires conditions unique to sleep. The absence of noradrenaline during sleep spindles and REM sleep as well as the low levels of serotonin during REM sleep allow the brain to integrate new memories and to refresh and renew old synapses so that we are ready to build new associations the next waking period. Memory difficulties involved in post-traumatic stress disorder, Schizophrenia, Alzheimer’s disease and even autism involve abnormalities in the sleep-dependent memory consolidation process that my lab studies. Keywords: Sleep, learning and memory, PTSD, memory consolidation, reconsolidation, REM sleep, sleep spindles, Norepinephrine, LTP, depotentiation, reversal learning, optogenetics, electrophysiology, tetrode recordings, hippocampus, prefrontal cortex.

Education

B.A., Human Biology, Stanford University 1987
Ph.D., Neuroscience, University of California, Los Angeles 1995

Selected Publications

Cao J, Herman AB, West GB, Poe G, Savage VM. Unraveling why we sleep: Quantitative analysis reveals abrupt transition from neural reorganization to repair in early development. Sci Adv 6(38):eaba0398 (11 pages), 2020. doi: 10.1126/sciadv.aba0398.

Guthrie R, Ciliberti D, Mankin E, Poe GR. Recurrent hippocampo-neocortical sleep-state divergence in humans. PNAS 119(44): e2123427119, PM36279474, 2022.

Frazer M, Cabrera Y, Guthrie R, Poe GR. Shining a light on the mechanisms of sleep for memory consolidation. Current Sleep Medicine Rep, 7:221-231, 2021. https://doi.org/10.1007/s40675-021-00204-3.

Cabrera Y, Holloway J, Poe GR (2020) ‘Sleep Changes Across the Female Hormonal Cycle Affecting Memory: Implications for Resilient Adaptation to Traumatic Experiences.’ J Womens Health (Larchmt), 29 (3): 446-451. PMID: 32186966

Swift KM, Keus K, Echeverria CG, Cabrera Y, Jimenez J, Holloway J, Clawson BC, Poe GR () ‘Sex differences within sleep in gonadally-intact rats.’ Sleep, 2019.PMID: 31784755

Swift KM, Gross BA, Frazer MA, Bauer DS, Clark KJD, Vazey EM, Aston-Jones G, Li Y, Pickering AE, Sara SJ, Poe GR (2018) ‘Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory.’ Curr Biol, 28 (22): 3599-3609.e4. PMID: 30393040

Zaborszky L, Gombkoto P, Varsanyi P, Poe GR, Role L, Ananth M, Rajebhosale P, Talmage D, Hasselmo M, Dannenberg H, Minces V, Chiba A, “Specific basal forebrain-cortical cholinergic circuits coordinate cognitive operations”, J Neurosci, 38 (44): 9446-9458 (2018).

Lewis P, Knoblich G, Poe GR, “Recasting reality: how memory replay in sleep boosts creative problem solving”, Trends Cogni Sci, 22 (6): 491-503 (2018).

Bjorness TE, Booth V, Poe GR (2018) ‘Hippocampal theta power pressure builds over non-REM sleep and dissipates within REM sleep episodes.’ Arch Ital Biol, 156 (3): 112-126. PMID: 30324607

Poe GR (2017) ‘Sleep Is for Forgetting.’ J Neurosci, 37 (3): 464-473. PMID: 28100731

Javanbakht, A and Poe, GR, “Behavioral neuroscience of circuits involved in arousal regulation”, The Neurobiology of PTSD, Ressler, K and Liberzon, I(Eds.), 130-147 (2016).

Emrick JJ, Gross BA, Riley BT, Poe GR (2016) ‘Different Simultaneous Sleep States in the Hippocampus and Neocortex.’ Sleep, 39 (12): 2201-2209. PMID: 27748240

Vanderheyden WM, George SA, Urpa L, Kehoe M, Liberzon I, Poe GR (2015) ‘Sleep alterations following exposure to stress predict fear-associated memory impairments in a rodent model of PTSD.’ Exp Brain Res, 233 (8): 2335-46. PMID: 26019008.

Watts A, Gritton HJ, Sweigart J, Poe GR (2012) ‘Antidepressant suppression of non-REM sleep spindles and REM sleep impairs hippocampus-dependent learning while augmenting striatum-dependent learning.’ J Neurosci, 32 (39): 13411-20. PMID: 23015432

Booth V, Poe GR (2006) ‘Input source and strength influences overall firing phase of model hippocampal CA1 pyramidal cells during theta: relevance to REM sleep reactivation and memory consolidation.’ Hippocampus, 16 (2): 161-73. PMID: 16411243

Steve Shoptaw

Steven Shoptaw, Ph.D.

Biography

Steve Shoptaw is a licensed psychologist and Professor in the UCLA Departments of Family Medicine and Psychiatry and Biobehavioral Sciences. Dr. Shoptaw joined the Department of Family Medicine as full professor in 2005. Prior to this, Dr. Shoptaw was a Research Psychologist with the Integrated Substance Abuse Program in the Dept. of Psychiatry & Behavioral Science since 2003. Dr. Shoptaw earned his BA (1982) in Psychology and MA (1985) and Ph.D. (1990) in Psychology at UCLA. His dissertation was nominated for the Gingerelli Award for Excellence in the Department of Psychology. Dr. Shoptaw completed his postdoctoral training in Psychophysiology at the UCLA NPI/VAMC in Sepulveda, CA in 1991. Following that, Dr. Shoptaw worked for 10 years as a Principal Investigator with Friends Research Institute, Inc., during which time, his program of clinical research with substance abusers supported opening several treatment research clinics in Rancho Cucamonga, Hollywood, South Los Angeles, and West Hollywood. Dr. Shoptaw received the FRI Daniel Mendelsohn Young Investigator Award in 1996 and a mentoring award in 2000. In 1996, Dr. Shoptaw opened Safe House, a 24 bed facility that provides emergency, transitional and permanent housing to persons living with HIV/AIDS, chemical dependency, transitional and permanent housing to persons living with HIV/AIDS, chemical dependency, and mental illness who are homeless or at risk for homelessness. He continues with this program as a volunteer Executive Director. These linkages of clinical research and community collaboration have led Dr. Shoptaw???s work to influence practice guidelines in intervening with substance abusers, especially those at high risk for HIV transmission, locally, nationally and in emerging international epidemics.

Publications

A selected list of publications:

Ling Murtaugh Kimberly, Krishnamurti Tamar, Davis Alexander L, Reback Cathy J, Shoptaw Steven   Spend today, clean tomorrow: Predicting methamphetamine abstinence in a randomized controlled trial Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2013; 32(9): 958-66.
Koblin Beryl A, Mayer Kenneth H, Eshleman Susan H, Wang Lei, Mannheimer Sharon, Del Rio Carlos, Shoptaw Steven, Magnus Manya, Buchbinder Susan, Wilton Leo, Liu Ting-Yuan, Cummings Vanessa, Piwowar-Manning Estelle, Fields Sheldon D, Griffith Sam, Elharrar Vanessa, Wheeler Darrell, Wheeler Darrell   Correlates of HIV Acquisition in a Cohort of Black Men Who Have Sex with Men in the United States: HIV Prevention Trials Network (HPTN) 061 PloS one, 2013; 8(7): e70413.
Landovitz Raphael J, Tseng Chi-Hong, Weissman Matthew, Haymer Michael, Mendenhall Brett, Rogers Kathryn, Veniegas Rosemary, Gorbach Pamina M, Reback Cathy J, Shoptaw Steven   Epidemiology, Sexual Risk Behavior, and HIV Prevention Practices of Men who Have Sex with Men Using GRINDR in Los Angeles, California Journal of urban health : bulletin of the New York Academy of Medicine, 2013; 90(4): 729-39.
Reback Cathy J, Fletcher Jesse B, Shoptaw Steven, Grella Christine E   Methamphetamine and other substance use trends among street-recruited men who have sex with men, from 2008 to 2011 Drug and alcohol dependence, 2013; 8(7): .
Swanson Aimee-Noelle, Shoptaw Steven, Heinzerling Keith Gregory, Wade Adam C, Worley Matthew, McCracken James, Wilson Sarah A, Asarnow Joan, London Edythe D   Up in Smoke? A Preliminary Open-Label Trial of Nicotine Replacement Therapy and Cognitive Behavioral Motivational Enhancement for Smoking Cessation Among Youth in Los Angeles Substance use & misuse, 2013; 8(7): .
Murphy Ryan D, Gorbach Pamina M, Weiss Robert E, Hucks-Ortiz Christopher, Shoptaw Steven J   Seroadaptation in a sample of very poor Los Angeles area men who have sex with men AIDS and behavior, 2013; 17(5): 1862-72.
Herrick Amy L, Stall Ron, Chmiel Joan S, Guadamuz Thomas E, Penniman Typhanye, Shoptaw Steven, Ostrow David, Plankey Michael W   It gets better: resolution of internalized homophobia over time and associations with positive health outcomes among MSM AIDS and behavior, 2013; 17(4): 1423-30.
Ding Yingying, He Na, Shoptaw Steven, Gao Meiyang, Detels Roger   Severity of club drug dependence and perceived need for treatment among a sample of adult club drug users in Shanghai, China Social psychiatry and psychiatric epidemiology, 2013; 17(5): .
Brensilver Matthew, Heinzerling Keith G, Shoptaw Steven   Pharmacotherapy of amphetamine-type stimulant dependence: An update Drug and alcohol review, 2013; 17(4): .
Heinzerling Keith G, Gadzhyan Janette, van Oudheusden Henry, Rodriguez Felipe, McCracken James, Shoptaw Steven   Pilot randomized trial of bupropion for adolescent methamphetamine abuse/dependence The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2013; 52(4): 502-5.
Herrick Amy L, Lim Sin How, Plankey Michael W, Chmiel Joan S, Guadamuz Thomas E, Guadamuz Thomas T, Kao Uyen, Shoptaw Steven, Carrico Adam, Ostrow David, Stall Ron   Adversity and syndemic production among men participating in the multicenter AIDS cohort study: a life-course approach American journal of public health, 2013; 103(1): 79-85.
Nyamathi Adeline, Salem Benissa, Reback Cathy J, Shoptaw Steven, Branson Catherine M, Idemundia Faith E, Kennedy Barbara, Khalilifard Farinaz, Marfisee Mary, Liu Yihang   Correlates of hepatitis B virus and HIV knowledge among gay and bisexual homeless young adults in Hollywood American journal of men’s health, 2013; 7(1): 18-26.
Reback Cathy J, Grant Deborah Ling, Fletcher Jesse B, Branson Catherine M, Shoptaw Steven, Bowers Jane Rohde, Charania Mahnaz, Mansergh Gordon   Erratum to: Text Messaging Reduces HIV Risk Behaviors Among Methamphetamine-Using Men Who Have Sex with Men AIDS and behavior, 2012; .
Strathdee Steffanie A, Shoptaw Steven, Dyer Typhanye Penniman, Quan Vu Minh, Aramrattana Apinun, Aramrattana Apinun   Towards combination HIV prevention for injection drug users: addressing addictophobia, apathy and inattention Current opinion in HIV and AIDS, 2012; 7(4): 320-325.
Landovitz Raphael J, Fletcher Jesse B, Inzhakova Galina, Lake Jordan E, Shoptaw Steven, Reback Cathy J   A Novel Combination HIV Prevention Strategy: Post-Exposure Prophylaxis with Contingency Management for Substance Abuse Treatment Among Methamphetamine-Using Men Who Have Sex with Men AIDS patient care and STDs, 2012; 26(6): 320-8.
Reback Cathy J, Grant Deborah Ling, Fletcher Jesse B, Branson Catherine M, Shoptaw Steven, Bowers Jane Rohde, Charania Mahnaz, Mansergh Gordon   Text Messaging Reduces HIV Risk Behaviors Among Methamphetamine-Using Men Who Have Sex with Men AIDS and behavior, 2012; 26(6): .
Brensilver Matthew, Heinzerling Keith G, Swanson Aimee-Noelle, Shoptaw Steven J   A retrospective analysis of two randomized trials of bupropion for methamphetamine dependence: Suggested guidelines for treatment discontinuation/augmentation Drug and alcohol dependence, 2012; 26(6): .
Heinzerling Keith G, Shoptaw Steven   Gender, brain-derived neurotrophic factor Val66Met, and frequency of methamphetamine use Gender medicine, 2012; 9(2): 112-20.
Brensilver Matthew, Heinzerling Keith G, Swanson Aimee-Noelle, Telesca Donatello, Furst Benjamin A, Shoptaw Steven J   Cigarette smoking as a target for potentiating outcomes for methamphetamine abuse treatment Drug and alcohol review, 2012; 9(2): .
Heinzerling Keith G, McCracken James T, Swanson Aimee-Noelle, Ray Lara A, Shoptaw Steven J   COMT Val158Met, BDNF Val66Met, and OPRM1 Asn40Asp and methamphetamine dependence treatment response: preliminary investigation Journal of clinical psychopharmacology, 2012; 32(1): 135-7.
Ling Walter, Shoptaw Steven, Hillhouse Maureen, Bholat Michelle A, Charuvastra Charles, Heinzerling Keith, Chim David, Annon Jeffrey, Dowling Patrick T, Doraimani Geetha   Double-blind placebo-controlled evaluation of the PROMETA™ protocol for methamphetamine dependence Addiction (Abingdon, England), 2012; 107(2): 361-9.
Xu Hongquan, Shen Qing, Yang Xiaowei, Shoptaw Steven   A quasi F-test for functional linear models with functional covariates and its application to longitudinal data Statistics in medicine, 2011; 30(23): 2842-53.
Ober Allison J, Iguchi Martin Y, Weiss Robert E, Gorbach Pamina M, Heimer Robert, Ouellet Lawrence J, Shoptaw Steven, Anglin M Douglas, Zule William A   The relative role of perceived partner risks in promoting condom use in a three-city sample of high-risk, low-income women AIDS and behavior, 2011; 15(7): 1347-58.
Tross Susan, Campbell Aimee N C, Calsyn Donald A, Metsch Lisa R, Sorensen James L, Shoptaw Steven, Haynes Louise, Woody George E, Malow Robert M, Brown Lawrence S, Feaster Daniel J, Booth Robert E, Mandler Raul N, Masson Carmen, Holmes Beverly W, Colfax Grant, Brooks Audrey J, Hien Denise A, Schackman Bruce R, Korthuis P Todd, Miele Gloria M, Miele Gloria M   NIDA’s Clinical Trials Network: an opportunity for HIV research in community substance abuse treatment programs The American journal of drug and alcohol abuse, 2011; 37(5): 283-93.
Young Sean D, Shoptaw Steven, Weiss Robert E, Munjas Brett, Gorbach Pamina M   Predictors of unrecognized HIV infection among poor and ethnic men who have sex with men in Los Angeles AIDS and behavior, 2011; 15(3): 643-9.
Igor Spigelman, Ph.D.

Igor Spigelman, Ph.D.

Publications

A selected list of publications:

Shen Yi, Lindemeyer A Kerstin, Spigelman Igor, Sieghart Werner, Olsen Richard W, Liang Jing   Plasticity of GABAA receptors after ethanol pre-exposure in cultured hippocampal neurons Molecular pharmacology, 2011; 79(3): 432-42.
Ruangsri Supanigar, Lin Audrey, Mulpuri Yatendra, Lee Kyung, Spigelman Igor, Nishimura Ichiro   RELATIONSHIP OF AXONAL VOLTAGE-GATED SODIUM CHANNEL 1.8 (NaV1.8) mRNA ACCUMULATION TO SCIATIC NERVE INJURY-INDUCED PAINFUL NEUROPATHY IN RATS The Journal of biological chemistry, 2011; .
Suryanarayanan Asha, Liang Jing, Meyer Edward M, Lindemeyer A Kerstin, Chandra Dev, Homanics Gregg E, Sieghart Werner, Olsen Richard W, Spigelman Igor   Subunit Compensation and Plasticity of Synaptic GABA(A) Receptors Induced by Ethanol in ?4 Subunit Knockout Mice Frontiers in neuroscience, 2011; 5(3): 110.
Díaz-Cintra Sofia, Xue Baogang, Spigelman Igor, Van K, Wong Alan M, Obenaus Andre, Ribak Charles E   Dentate granule cells form hilar basal dendrites in a rat model of hypoxia-ischemia Brain research, 2009; 1285: 182-7.
Thakor Devang Kashyap, Lin Audrey, Matsuka Yoshizo, Meyer Edward M, Ruangsri Supanigar, Nishimura Ichiro, Spigelman Igor   Increased peripheral nerve excitability and local NaV1.8 mRNA up-regulation in painful neuropathy Molecular pain, 2009; 5(1): 14.
Ribak Charles E, Shapiro Lee A, Perez Zachary D, Spigelman Igor   Microglia-associated granule cell death in the normal adult dentate gyrus Brain structure & function, 2009; .
Matsuka Yoshizo, Ono Takeshi, Iwase Hirotate, Mitrirattanakul Somsak, Omoto Kevin S, Cho Ting, Lam Yan Yan N, Snyder Bradley, Spigelman Igor   Altered ATP release and metabolism in dorsal root ganglia of neuropathic rats Molecular pain, 2008; 4(1): 66.
Jain Naveen K, Ishikawa Tomo-o, Spigelman Igor, Herschman Harvey R   COX-2 expression and function in the hyperalgesic response to paw inflammation in mice Prostaglandins, leukotrienes, and essential fatty acids, 2008; 79(6): 183-90.
Liang Jing, Suryanarayanan Asha, Chandra Dev, Homanics Gregg E, Olsen Richard W, Spigelman Igor   Functional consequences of GABAA receptor alpha 4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells Alcoholism, clinical and experimental research, 2008; 32(1): 19-26.
Chandra Dev, Werner David F, Liang Jing, Suryanarayanan Asha, Harrison Neil L, Spigelman Igor, Olsen Richard W, Homanics Gregg E   Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice Alcoholism, clinical and experimental research, 2008; 32(1): 10-8.
Mitrirattanakul Somsak, López-Valdés Héctor E, Liang Jing, Matsuka Yoshizo, Mackie Ken, Faull Kym F, Spigelman Igor   Bidirectional alterations of hippocampal cannabinoid 1 receptors and their endogenous ligands in a rat model of alcohol withdrawal and dependence Alcoholism, clinical and experimental research, 2007; 31(5): 855-67.
Liang Jing, Suryanarayanan Asha, Abriam Alana, Snyder Bradley, Olsen Richard W, Spigelman Igor   Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(45): 12367-77.
Thakor Devang, Spigelman Igor, Tabata Yasuhiko, Nishimura Ichiro   Subcutaneous peripheral injection of cationized gelatin/DNA polyplexes as a platform for non-viral gene transfer to sensory neurons Molecular therapy : the journal of the American Society of Gene Therapy, 2007; 15(12): 2124-31.
Liang, J., Zhang, N., Cagetti, E. Houser, C.R., Olsen, R.W. and Spigelman, I.   Chronic intermittent ethanol treatment-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors, Journal of Neuroscience, 2006; 26: 1749-1758.
Liang Jing, Zhang Nianhui, Cagetti Elisabetta, Houser Carolyn R, Olsen Richard W, Spigelman Igor   Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006; 26(6): 1749-58.
Chandra, D., Jia, F., Liang, J., Peng, Z., Suryanarayanan, A., Werner, D.F., Spigelman, I., Houser, C.R., Olsen, R.W., Harrison, N.L. and Homanics, G.E.   GABA(A) receptor alpha4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol, Proceedings of the National Academy of Sciences USA, 2006; 103: 15230-15235.
Spigelman, I.   Physiologic mechanisms of inhibition and status epilepticus, In: Status Epilepticus, Mechanisms and Management, C.G. Wasterlain and D.M. Treiman editors, MIT Press, Cambridge,, 2006; Chapter 21: 281-293.
Mitrirattanakul Somsak, Ramakul Navapoln, Guerrero Andre V, Matsuka Yoshizo, Ono Takeshi, Iwase Hirotate, Mackie Ken, Faull Kym F, Spigelman Igor   Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain Pain, 2006; 126(1-3): 102-14.
Olsen, R.W., Liang, J., Cagetti, E., and Spigelman, I.   Plasticity of GABAA receptors in brains of rats treated with chronic intermittent ethanol , Neurochemical Research, 2005; 30: 1579-1588.
Matsuka Y. and Spigelman, I.   Hyperosmolar solutions selectively block action potentials in rat myelinated sensory fibers: implications for diabetic neuropathy, Journal of Neurophysiology, 2004; 91: 48-56.
Matsuka, Y Neubert, JK Maidment, NT Spigelman, I   Concurrent release of ATP and substance P within guinea pig trigeminal ganglia in vivo Brain research. , 2001; 915(2): 248-55.
Spigelman, I., Gold, M.S., Light A.R.   Electrophysiological Methods in Pain Research, Methods in Pain Research, 2001; Chapter 8: 147-168.
Spigelman, I., Neubert, J.K., Matsuka, Y., Maidment, N.T.   Extracellular Sampling, Methods in Pain Research, 2001; Chapter 7: 133-146.
Neubert, JK Maidment, NT Matsuka, Y Adelson, DW Kruger, L Spigelman, I   Inflammation-induced changes in primary afferent-evoked release of substance P within trigeminal ganglia in vivo Brain research. , 2000; 871(2): 181-91.
Spigelman, I Yan, XX Obenaus, A Lee, EY Wasterlain, CG Ribak, CE   Dentate granule cells form novel basal dendrites in a rat model of temporal lobe epilepsy Neuroscience. , 1998; 86(1): 109-20.
Spigelman, I Obenaus, A Mazarati, A Wasterlain, CG   Intravenously administered cell-permeant calcium buffer decreases evoked synaptic potentials in rat dentate gyrus in vivo Brain research. , 1998; 810(1-2): 269-73.
Catherine Cahill, Ph.D.

Catherine Cahill, M.Sc., Ph.D.

Biography

Catherine M. Cahill, Ph.D. trained as an opioid neuropharmaoclogist at Dalhousie University, Canada receiving her PhD in 1996. She was recruited to the Department of Anesthesiology and Perioperative Care at University of California Irvine in 2012 from Queen’s University in Canada where she held a Canada Research Chair in Chronic Pain for 10 years. She moved to UCLA in 2017 and is now a Professor in the Department of Psychiatry & Biobehavioral Sciences and a member of the Hatos Center for Neuropharmacology at the University of California Los Angeles.

She has more than 25 years experience in research that focuses on understanding mechanisms of chronic pain and opioid analgesia, tolerance, dependence and addiction. Her research spans both basic science and human research, which focuses on how chronic pain states modulate reward circuitry and changes dopaminergic transmission responsible for motivated behavior. A large emphasis of her research focuses on understanding the processes that influence the positive and negative reinforcement and changes in mesolimbic circuitry in order to identify novel treatment strategies for opioid dependence and chronic pain.

Dr. Cahill’s research is supported by the National Institutes of Drug abuse, the National Center for Advancing Translational Sciences, the National Institute of Aging, the National Institute of Dental and Craniofacial Research, the Department of Defense and the Shirley and Stefan Hatos Foundation.

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