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Timothy Fong

Timothy Fong, M.D.

Biography

Dr. Fong is a Professor of Psychiatry, board-certified in Addiction Psychiatry, at the Semel Institute for Neuroscience and Human Behavior at UCLA.    

Publications

A selected list of publications:

Fong Timothy W, Reid Rory C, Parhami Iman   Behavioral addictions: where to draw the lines? The Psychiatric clinics of North America, 2012; 35(2): 279-96.
Fink Arlene, Parhami Iman, Rosenthal Richard J, Campos Michael D, Siani Aaron, Fong Timothy W   How Transparent is Behavioral Intervention Research on Pathological Gambling and Other Gambling-Related Disorders? A Systematic Literature Review Addiction (Abingdon, England), 2012; 35(2): .
Parhami Iman, Davtian Margarit, Collard Michael, Lopez Jean, Fong Timothy W   A Preliminary 6-Month Prospective Study Examining Self-reported Religious Preference, Religiosity/Spirituality, and Retention at a Jewish Residential Treatment Center for Substance-Related Disorders The journal of behavioral health services & research, 2012; 35(2): .
Parhami Iman, Siani Aaron, Rosenthal Richard J, Fong Timothy W   Pathological Gambling, Problem Gambling and Sleep Complaints: An Analysis of the National Comorbidity Survey: Replication (NCS-R) Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming, 2012; 35(2): .
Parhami Iman, Hyman Mark, Siani Aaron, Lin Stephanie, Collard Michael, Garcia Johnny, Casaus Laurie, Tsuang John, Fong Timothy W   Screening for addictive disorders within a workers’ compensation clinic: an exploratory study Substance use & misuse, 2012; 47(1): 99-107.
Parhami Iman, Siani Aaron, Rosenthal Richard J, Lin Stephanie, Collard Michael, Fong Timothy W   Sleep and gambling severity in a community sample of gamblers Journal of addictive diseases, 2012; 31(1): 67-79.
Reid Rory C, Carpenter Bruce N, Fong Timothy W   Neuroscience research fails to support claims that excessive pornography consumption causes brain damage Surgical neurology international, 2011; 2(1): 64.
Fong Timothy W, Campos Michael D, Brecht Mary-Lynn, Davis Alice, Marco Adrienne, Pecanha Viviane, Rosenthal Richard J   Problem and pathological gambling in a sample of casino patrons Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming, 2011; 27(1): 35-47.
Xu Jiansong, Azizian Allen, Monterosso John, Domier Catherine P, Brody Arthur L, Fong Timothy W, London Edythe D   Gender effects on mood and cigarette craving during early abstinence and resumption of smoking Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2008; 10(11): 1653-61.
Payer Doris E, Lieberman Matthew D, Monterosso John R, Xu Jiansong, Fong Timothy W, London Edythe D   Differences in cortical activity between methamphetamine-dependent and healthy individuals performing a facial affect matching task Drug and alcohol dependence, 2008; 93(1-2): 93-102.
Fong Timothy W, Tsuang John   Asian-americans, addictions, and barriers to treatment Psychiatry (Edgmont (Pa. : Township)), 2007; 4(11): 51-9.
Fong Timothy W   Understanding and managing compulsive sexual behaviors Psychiatry (Edgmont (Pa. : Township)), 2006; 3(11): 51-8.
Fong Timothy W, De La Garza Richard, Newton Thomas F   A case report of topiramate in the treatment of nonparaphilic sexual addiction Journal of clinical psychopharmacology, 2005; 25(5): 512-4.
Fong Timothy W   Types of psychotherapy for pathological gamblers Psychiatry (Edgmont (Pa. : Township)), 2005; 2(5): 32-9.
Fong Timothy W   The vulnerable faces of pathological gambling Psychiatry (Edgmont (Pa. : Township)), 2005; 2(4): 34-42.
Fong Timothy W   The biopsychosocial consequences of pathological gambling Psychiatry (Edgmont (Pa. : Township)), 2005; 2(3): 22-30.
Tsuang John, Fong Timothy W   Treatment of patients with schizophrenia and substance abuse disorders Current pharmaceutical design, 2004; 10(18): 2249-61.

Alicia Izquierdo, Ph.D.

Publications

A selected list of publications:

González VV, Zhang Y, Ashikyan SA, Rickard A, Yassine I, Romero-Sosa JL, Blaisdell AP, Izquierdo A (2024). A special role for anterior cingulate cortex, but not orbitofrontal cortex or basolateral amygdala, in choices involving information. Cerebral Cortex 34(4): bhae135.

Aguirre CG, Woo JH, Romero-Sosa JL, Rivera ZM, Tejada AN, Munier JJ, Perez J, Goldfarb M, Das K, Gomez M, Ye T, Pannu J, Evans K, O’Neill PR, Spigelman I, Soltani A, Izquierdo A (2024). Dissociable contributions of basolateral amygdala and ventrolateral orbitofrontal cortex to flexible learning under uncertainty. The Journal of Neuroscience 44(2): e0622232023.

Ye T, Romero-Sosa JL, Rickard A, Aguirre CG, Wikenheiser AM, Blair HT, Izquierdo A (2023). Theta oscillations in anterior cingulate cortex and orbitofrontal cortex differentially modulate accuracy and speed in flexible reward learning. Oxford Open Neuroscience 2: kvad005.

Hart EE, Blair GJ, O’Dell TJ, Blair HT, Izquierdo A (2020). Chemogenetic modulation and single-photon calcium imaging in anterior cingulate cortex reveal a mechanism for effort-based decisions. The Journal of Neuroscience 40 (29) 5628-5643.

Stolyarova A, Rakhshan M, Hart EE, O’Dell TJ, Peters MAK, Lau H, Soltani A, Izquierdo A (2019). Contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty. Nature Communications 10: 4704.

Soltani A and Izquierdo A (2019). Adaptive learning under expected and unexpected uncertainty. Nat Rev Neurosci doi: 10.1038/s41583-019-0180-y.

Edythe D. London, Ph.D.

Edythe London, Ph.D.

Biography

Dr. London received her Ph.D. in Pharmacology from the University of Maryland and  postdoctoral training at Johns Hopkins School of Medicine. Before coming to UCLA in 2001, she was the Director of the Brain Imaging Center for the National Institute on Drug Abuse and held faculty appointments at the University of Maryland and Johns Hopkins Schools of Medicine. Dr. London is a Distinguished Professor-in-Residence in the Departments of Psychiatry and Biobehavioral Sciences and Molecular and Medical Pharmacology. Her work focuses on the use of neuroimaging to study neural circuitry underlying self-control and behaviors related to addiction.

She has received numerous awards, including the Nathan B. Eddy Lifetime Achievement Award from the College on Problems of Drug Dependence (2023), the McLean Hospital Women in Science Lectureship (2020), the H.W. Magoun Lectureship at UCLA (2019), and the Scientific Freedom & Responsibility Award from the American Association for the Advancement of Science (2011).

Publications

Representative Recent Publications 

  1. McClintick MN, Kessler RM, Mandelkern MA, Mahmoudie T, Allen DC, Lachoff H, Pochon JF, Ghahremani DG, Farahi JB, Partiai E, Casillas RA, Mooney LJ, Dean AC, London ED. Brain mGlu5 Is Linked to Cognition and Cigarette Smoking but Does Not Differ From Control in Early Abstinence From Chronic Methamphetamine Use.. The international journal of neuropsychopharmacology, 2024.
  2. Jarrett O, London ED, Mahmoudie T, Suh J, Ghahremani D, Dean AC. Mindfulness and clinical correlates in methamphetamine use disorder. Drug and alcohol dependence, 2023.
  3. O’Neill J, Diaz MP, Alger JR, Pochon JB, Ghahremani D, Dean AC, Tyndale RF, Petersen N, Marohnic S, Karaiskaki A, London ED. Smoking, tobacco dependence, and neurometabolites in the dorsal anterior cingulate cortex. Molecular psychiatry, 2023.
  4. Tabibnia G, Ghahremani DG, Pochon JF, Diaz MP, London ED. Negative affect and craving during abstinence from smoking are both linked to default mode network connectivity. Drug and alcohol dependence, 2023.
  5. Guttman Z, Mandelkern M, Ghahremani DG, Kohno M, Dean AC, London ED. Decomposing risky decision-making in methamphetamine use disorder: Behavioral updating and D2 dopamine receptors. Drug and alcohol dependence, 2023.
  6. Ghahremani DG, Pochon JF, Diaz MP, Tyndale RF, Dean AC, London ED. Nicotine dependence and insula subregions: functional connectivity and cue-induced activation. Neuropsychopharmacology, 2023.
  7. Nestor LJ, Ghahremani DG, London ED. Reduced neural functional connectivity during working memory performance in methamphetamine use disorder. Drug and alcohol dependence, 2023.
  8. Rice M, Dean AC, Suh J, London ED. Denial and Diagnosis of Methamphetamine Dependence Severity. Substance abuse: research and treatment, 2022.
  9. Zorick T, Okita K, Renard KB, Mandelkern MA, Brody AL, London ED. The Effects of Citalopram and Thalamic Dopamine D2/3 Receptor Availability on Decision-Making and Loss Aversion in Alcohol Dependence.. Psychiatry journal, 2022.
  10. Petzold J, Dean AC, Pochon JB, Ghahremani DG, De La Garza R, London ED. Cortical thickness and related depressive symptoms in early abstinence from chronic methamphetamine use. Addiction biology, 2022.
  11. Ottino-González J, Garavan H, ENIGMA-Addiction and IMAGEN consortiums. Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents. Addiction (Abingdon, England), 2022.
  12. Ekhtiari H, Zare-Bidoky M, Sangchooli A, Janes AC, Kaufman MJ, Oliver JA, Prisciandaro JJ, Wüstenberg T, Anton RF, Bach P, Baldacchino A, Beck A, Bjork JM, Brewer J, Childress AR, Claus ED, Courtney KE, Ebrahimi M, Filbey FM, Ghahremani DG, Azbari PG, Goldstein RZ, Goudriaan AE, Grodin EN, Hamilton JP, Hanlon CA, Hassani-Abharian P, Heinz A, Joseph JE, Kiefer F, Zonoozi AK, Kober H, Kuplicki R, Li Q, London ED, McClernon J, Noori HR, Owens MM, Paulus MP, Perini I, Potenza M, Potvin S, Ray L, Schacht JP, Seo D, Sinha R, Smolka MN, Spanagel R, Steele VR, Stein EA, Steins-Loeber S, Tapert SF, Verdejo-Garcia A, Vollstädt-Klein S, Wetherill RR, Wilson SJ, Witkiewitz K, Yuan K, Zhang X, Zilverstand A. A methodological checklist for fMRI drug cue reactivity studies: development and expert consensus. Nature protocols, 2022.
  13. Wolitzky-Taylor K, Glasner S, Tanner A, Ghahremani DG, London ED. Targeting maladaptive reactivity to negative affect in emerging adults with cannabis use disorder: A preliminary test and proof of concept.. Behaviour research and therapy, 2022.
  14. Ottino-González J, Uhlmann A, Hahn S, Cao Z, Cupertino RB, Schwab N, Allgaier N, Alia-Klein N, Ekhtiari H, Fouche JP, Goldstein RZ, Li CR, Lochner C, London ED, Luijten M, Masjoodi S, Momenan R, Oghabian MA, Roos A, Stein DJ, Stein EA, Veltman DJ, Verdejo-García A, Zhang S, Zhao M, Zhong N, Jahanshad N, Thompson PM, Conrod P, Mackey S, Garavan H. White matter microstructure differences in individuals with dependence on cocaine, methamphetamine, and nicotine: Findings from the ENIGMA-Addiction working group. Drug and alcohol dependence, 2021.
  15. Perez Diaz M, Pochon JB, Ghahremani DG, Dean AC, Faulkner P, Petersen N, Tyndale RF, Donis A, Paez D, Cahuantzi C, Hellemann GS, London ED. Sex Differences in the Association of Cigarette Craving With Insula Structure. The international journal of neuropsychopharmacology, 2021.
  16. Guttman ZR, Ghahremani DG, Pochon JB, Dean AC, London ED. Age Influences Loss Aversion Through Effects on Posterior Cingulate Cortical Thickness. Frontiers in neuroscience, 2021.
  17. Ghahremani DG, Pochon JB, Perez Diaz M, Tyndale RF, Dean AC, London ED. Functional connectivity of the anterior insula during withdrawal from cigarette smoking. Neuropsychopharmacology, 2021.
  18. van Nunen LJ, Lake MT, Ipser JC, Stein DJ, Shoptaw SJ, London ED. Executive Function and Contingency Management in Methamphetamine Use Disorder. Journal of alcoholism and drug dependence, 2021.
  19. Petzold J, Szumlinski KK, London ED. Targeting mGlu5 for Methamphetamine Use Disorder. Pharmacology & therapeutics, 2021.
  20. Cao Z, Ottino-Gonzalez J, Cupertino RB, Schwab N, Hoke C, Catherine O, Cousijn J, Dagher A, Foxe JJ, Goudriaan AE, Hester R, Hutchison K, Li CR, London ED, Lorenzetti V, Luijten M, Martin-Santos R, Momenan R, Paulus MP, Schmaal L, Sinha R, Sjoerds Z, Solowij N, Stein DJ, Stein EA, Uhlmann A, van Holst RJ, Veltman DJ, Wiers RW, Yücel M, Zhang S, Jahanshad N, Thompson PM, Conrod P, Mackey S, Garavan H. Mapping cortical and subcortical asymmetries in substance dependence: Findings from the ENIGMA Addiction Working Group.. Addiction biology, 2021.
  21. Petersen N, Kearley NW, Ghahremani DG, Pochon JB, Fry ME, Rapkin AJ, London ED. Effects of oral contraceptive pills on mood and magnetic resonance imaging measures of prefrontal cortical thickness. Molecular psychiatry, 2021.
  22. Petersen N, Rapkin AJ, Okita K, Kinney KR, Mizuno T, Mandelkern MA, London ED. Striatal dopamine D2-type receptor availability and peripheral 17β-estradiol. Molecular psychiatry, 2021.
  23. Nie L, Ghahremani DG, Mandelkern MA, Dean AC, Luo W, Ren A, Li J, London ED. The relationship between duration of abstinence and gray-matter brain structure in chronic methamphetamine users. The American journal of drug and alcohol abuse, 2021.
  24. Burnette EM, Grodin EN, Ghahremani DG, Galván A, Kohno M, Ray LA, London ED. Diminished cortical response to risk and loss during risky decision making in alcohol use disorder. Drug and alcohol dependence, 2020.
  25. Hahn S, Mackey S, Cousijn J, Foxe JJ, Heinz A, Hester R, Hutchinson K, Kiefer F, Korucuoglu O, Lett T, Li CR, London E, Lorenzetti V, Maartje L, Momenan R, Orr C, Paulus M, Schmaal L, Sinha R, Sjoerds Z, Stein DJ, Stein E, van Holst RJ, Veltman D, Walter H, Wiers RW, Yucel M, Thompson PM, Conrod P, Allgaier N, Garavan H. Predicting alcohol dependence from multi-site brain structural measures. Human brain mapping, 2020.
  26. Dean AC, Nurmi EL, Morales AM, Cho AK, Seaman LC, London ED. CYP2D6 genotype may moderate measures of brain structure in methamphetamine users.. Addiction biology, 2020.
  27. Faulkner P, Dean AC, Ghahremani DG, London ED. Neural Basis of Smoking-Related Difficulties in Emotion Regulation.. The international journal of neuropsychopharmacology, 2020.
  28. Bari AA, Sparks H, Levinson S, Wilson B, London ED, Langevin JP, Pouratian N. Amygdala Structural Connectivity Is Associated With Impulsive Choice and Difficulty Quitting Smoking.. Frontiers in behavioral neuroscience, 2020.
  29. London ED, Okita K, Kinney KR, Dean AC, McClintick MN, Rizor EJ, Johnson MC, Mahmoudie T, Brody AL, Nurmi EL, Seaman LC, Farahi J, Ginder N, Mandelkern MA. No significant elevation of translocator protein binding in the brains of recently abstinent methamphetamine users. Drug and alcohol dependence, 2020.
  30. Thorberg FA, Hasking P, Huang YL, Lyvers M, Young RM, Connor JP, London ED, Feeney GFX. The Influence of Alexithymia on Alcohol Craving, Health-Related Quality of Life and Gender in Alcohol-Dependent Outpatients. Journal of psychoactive drugs, 2020.
  31. Moeller SJ, Kundu P, Bachi K, Maloney T, Malaker P, Parvaz MA, Alia-Klein N, London ED, Goldstein RZ. Self-awareness of problematic drug use: Preliminary validation of a new fMRI task to assess underlying neurocircuitry. Drug and alcohol dependence, 2020.
  32. Lake MT, Shoptaw S, Ipser JC, Takada S, van Nunen LJ, Lipinska G, Stein DJ, London ED. Decision-Making by Patients With Methamphetamine Use Disorder Receiving Contingency Management Treatment: Magnitude and Frequency Effects. Frontiers in psychiatry, 2020.
  33. London ED. Human Brain Imaging Links Dopaminergic Systems to Impulsivity. Current topics in behavioral neurosciences, 2020.
  34. Okafor CN, Stein DJ, Dannatt L, Ipser J, van Nunen LJ, Lake MT, Krishnamurti T, London ED, Shoptaw S. Contingency management treatment for methamphetamine use disorder in South Africa. Drug and alcohol review, 2019.
  35. Petersen N, Ghahremani DG, Rapkin AJ, Berman SM, Wijker N, Liang L, London ED. Resting-state functional connectivity in women with PMDD.. Translational psychiatry, 2019.
  36. Petzold J, Lee Y, Pooseh S, Oehme L, Beuthien-Baumann B, London ED, Goschke T, Smolka MN. Presynaptic dopamine function measured with [18F]fluorodopa and L-DOPA effects on impulsive choice.. Scientific reports, 2019.
  37. Chye Y, Mackey S, Gutman BA, Ching CRK, Batalla A, Blaine S, Brooks S, Caparelli EC, Cousijn J, Dagher A, Foxe JJ, Goudriaan AE, Hester R, Hutchison K, Jahanshad N, Kaag AM, Korucuoglu O, Li CR, London ED, Lorenzetti V, Luijten M, Martin-Santos R, Meda SA, Momenan R, Morales A, Orr C, Paulus MP, Pearlson G, Reneman L, Schmaal L, Sinha R, Solowij N, Stein DJ, Stein EA, Tang D, Uhlmann A, van Holst R, Veltman DJ, Verdejo-Garcia A, Wiers RW, Yücel M, Thompson PM, Conrod P, Garavan H. Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study. Addiction biology, 2019.
  38. Lam M, Hill WD, Trampush JW, Yu J, Knowles E, Davies G, Stahl E, Huckins L, Liewald DC, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, DeRosse P, Lundervold AJ, Steen VM, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Hartmann AM, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Chiba-Falek O, Attix DK, Need AC, Cirulli ET, Voineskos AN, Stefanis NC, Avramopoulos D, Hatzimanolis A, Arking DE, Smyrnis N, Bilder RM, Freimer NA, Cannon TD, London E, Poldrack RA, Sabb FW, Congdon E, Conley ED, Scult MA, Dickinson D, Straub RE, Donohoe G, Morris D, Corvin A, Gill M, Hariri AR, Weinberger DR, Pendleton N, Bitsios P, Rujescu D, Lahti J, Le Hellard S, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK, Lencz T. Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.. American journal of human genetics, 2019.
  39. Burggren AC, Shirazi A, Ginder N, London ED. Cannabis effects on brain structure, function, and cognition: considerations for medical uses of cannabis and its derivatives. The American journal of drug and alcohol abuse, 2019.
  40. Liu Y, van den Wildenberg WPM, de Graaf Y, Ames SL, Baldacchino A, Bø R, Cadaveira F, Campanella S, Christiansen P, Claus ED, Colzato LS, Filbey FM, Foxe JJ, Garavan H, Hendershot CS, Hester R, Jester JM, Karoly HC, Kräplin A, Kreusch F, Landrø NI, Littel M, Loeber S, London ED, López-Caneda E, Lubman DI, Luijten M, Marczinski CA, Metrik J, Montgomery C, Papachristou H, Mi Park S, Paz AL, Petit G, Prisciandaro JJ, Quednow BB, Ray LA, Roberts CA, Roberts GMP, de Ruiter MB, Rupp CI, Steele VR, Sun D, Takagi M, Tapert SF, van Holst RJ, Verdejo-Garcia A, Vonmoos M, Wojnar M, Yao Y, Yücel M, Zack M, Zucker RA, Huizenga HM, Wiers RW. Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders.. Neuroscience and biobehavioral reviews, 2019.
  41. Petzold J, Kienast A, Lee Y, Pooseh S, London ED, Goschke T, Smolka MN. Baseline impulsivity may moderate L-DOPA effects on value-based decision-making.. Scientific reports, 2019.
  42. Zorick T, Okita K, Mandelkern MA, London ED, Brody AL. Effects of Citalopram on Cue-Induced Alcohol Craving and Thalamic D2/3 Dopamine Receptor Availability. The international journal of neuropsychopharmacology, 2019.
  43. Tang J, O’Neill J, Alger JR, Shen Z, Johnson MC, London ED. N-Acetyl and Glutamatergic Neurometabolites in Perisylvian Brain Regions of Methamphetamine Users. The international journal of neuropsychopharmacology, 2019.
  44. Burggren AC, Siddarth P, Mahmood Z, London ED, Harrison TM, Merrill DA, Small GW, Bookheimer SY. Subregional Hippocampal Thickness Abnormalities in Older Adults with a History of Heavy Cannabis Use.. Cannabis and cannabinoid research, 2018.
  45. Brody AL, Gehlbach D, Garcia LY, Enoki R, Hoh C, Vera D, Kotta KK, London ED, Okita K, Nurmi EL, Seaman LC, Mandelkern MA. Effect of overnight smoking abstinence on a marker for microglial activation: a [11C]DAA1106 positron emission tomography study.. Psychopharmacology, 2018.
  46. Faulkner P, Ghahremani DG, Tyndale RF, Paterson NE, Cox C, Ginder N, Hellemann G, London ED. Neural basis of smoking-induced relief of craving and negative affect: Contribution of nicotine. Addiction biology, 2018.
  47. Faulkner P, Ghahremani DG, Tyndale RF, Hellemann G, London ED. Functional Connectivity of the Raphe Nuclei: Link to Tobacco Withdrawal in Smokers. The international journal of neuropsychopharmacology, 2018.
  48. Petersen N, London ED. Addiction and Dopamine: Sex Differences and Insights from Studies of Smoking. Current opinion in behavioral sciences, 2018.
  49. Dean AC, Morales AM, Hellemann G, London ED. Cognitive deficit in methamphetamine users relative to childhood academic performance: link to cortical thickness. Neuropsychopharmacology, 2018.
  50. Ghahremani DG, Faulkner P, M Cox C, London ED. Behavioral and neural markers of cigarette-craving regulation in young-adult smokers during abstinence and after smoking.. Neuropsychopharmacology, 2018.
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