Amy Gleichman

Image of the Month

Vestibular cristae ampullares of a bat and mouse showing immunolabeled calyces (special-izations of afferent neurons). Inset: isolated calyx (mad translucent) and encapsulated hair cell (scale = 5 µm). Greater density of calretinin-positive calyces in bats represent a cellular adaptation supporting highly agile behavior.

By: Ymi Ton & Terry Prins  Larry Hoffman & Walter Metzner Laboratories


The Neuroscience Interdepartmental Program


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Upcoming Events

Joint Seminars in Neuroscience Lecture Series

Tuesday, February 20th, 2018
12:00pm - 1:00pm
Neuroscience Research Building (NRB) 1st Floor Auditorium

Bita Moghaddam, Ph.D.

Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon

"Translation of Anxiety into Actions by Prefrontal Cortex Neurons"


The prefrontal cortex (PFC) has been dubbed the “doer cortex” with a primary role of representing and selecting purposeful actions.  In the context of psychiatric disorders, much of the neuronal data and computational work on the PFC encoding of behavior focuses on the representation (or perception) of internal and external events that precede these actions. We have been interested in the encoding of goal-directed actions per se by PFC neurons and how it is affected by anxiety. The focus on anxiety stems from the fact that its relevance to mental health extends well beyond anxiety disorders. Critically, anxiety is a debilitating symptom of most psychiatric disorders including PTSD, major depression, autism, schizophrenia and addiction. Anxiety is often studied as a stand-alone construct in laboratory animals that focuses on fear responses. But in the context of coping with real-life anxiety, its negative impacts extend beyond aversive feelings to involve disruptions in ongoing goal-directed behaviors and cognitive functioning. I will present data from two distinct models of anxiety that allowed us to perform ensemble and local field potential recordings during reward-guided goal-directed behaviors.  We find that anxiety diminishes the recruitment of action encoding neurons and the coordinated activity between PFC and dopamine neurons. These results provide mechanistic insight for how anxiety diminishes rule-based guidance of behavior and single out encoding of actions, as opposed to cues or outcomes, by PFC neurons as particularly vulnerable to anxiety. 


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