Theresa Harrison

BRI member leads study showing how a molecular receptor helps restore brain function after 'silent stroke'

S. Thomas Carmichael, M.D., Ph.D., professor of neurology at the David Geffen School of Medicine, is senior author of a five year study that shows how the brain can be repaired and brain function recovered after a stroke in animals.

The discovery could have important implications for treating a mind-robbing condition known as a white matter stroke, which is a major form of dementia. "Despite how common and devastating white matter stroke is, there has been little understanding of how the brain responds and if it can recover," Dr. Carmichael said. "By studying the mechanisms and limitations of brain repair in this type of stroke, we will be able to identify new therapies to prevent disease progression and enhance recovery."

The study was published in the Proceedings of the National Academy of Sciences (December 27th, 2016).

More details here.

Image left: New brain cells replace those destroyed by stroke in animals: immature cells are green, more mature cells are red and fully mature cells are orange.



Image of the Month

Sensory innervation along the scales of adult zebrafish.  The peripheral axons of dorsal root ganglion neurons are labeled in green (p2rx.3a>mCherry); keratinocytes are labeled in magenta (krt4:GFP).

By: Jeff Rasmussen – Laboratory of Dr. Alvaro Sagasti




In the News Image

Announcing the Inaugural Recipients of the BRI Knaub Fellowship in Multiple Sclerosis Research 

Funded by a generous gift from the Knaub Unitrust, established by Richard and Suzanne Knaub, the fellowships support Postdoctoral or Predoctoral Fellows pursuing projects related to Multiple Sclerosis research at UCLA. The fellowships recognize young scientists who exemplify trainee excellence, innovation, and a multidisciplinary approach to MS research. 

The inaugural Knaub Fellows are Stefano Lepore, Ph.D. from the laboratory of Allan Mackenzie-Graham, Ph.D.; and David DiTullio from the laboratory of S. Thomas Carmichael, M.D., Ph.D. 

"We want to express our sincere gratitude to the Knaub family for this generous gift which will enable these young researchers to contribute to translational research related to understanding and treating MS," said BRI Director Christopher Evans.

Learn more about the 2017 Knaub Fellows here.



The Neuroscience Interdepartmental Program


Graduate Program

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Upcoming Events

Joint Seminars in Neuroscience Lecture Series

Tuesday, May 2, 2017
12:00noon - 1:00pm

Dr. Steven Siegelbaum, Ph.D.
Departments of Neuroscience and Pharmacology

Zuckerman Mind Brain Behavior Institute
Columbia University
New York, NY

"The Hippocampal CA2 Region and the Search for the Social Engram"

Studies of the neural circuitry underlying declarative memory have focused on the well-studied dentate gyrus, CA3 and CA1 regions of the hippocampus. Our research examines the long-neglected CA2 region. We find that CA2 serves as the nexus of divergent parallel neural circuits that regulate social memory, the ability of an animal to recognize a conspecific, and social aggression. We also find that alterations in CA2 neural activity are likely to contribute to altered social behavior associated with neuropsychiatric disorders.





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