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JOINT SEMINARS IN NEUROSCIENCE PRESENTS
TUESDAY, MAY 10TH, 2016 AT 12:00 NOON
Speaker: ROGER SUNAHARA, PH.D.
Department of Pharmacology
UC San Diego
Title: "Probing G Protein-Coupled Receptors as Allosteric Sensors Linking Hormone Binding to G Protein Activiation"
G protein-coupled receptors (GPCR) are vital communication systems that sense extracellular stimuli and transduce signals across the plasma membrane to intracellular compartments. They serve as sensors for environmental stimuli such as light, odors and tastes, as well as serving the receptors for hormones, chemokines and even pathogens. GPCRs couple to effectors systems that regulate second messengers such as cAMP, cations, and inositol phosphates, through interacting with the heterotrimeric family of G proteins. Recent advances in the structural biology of G protein-coupled receptors by themselves or more recently bound to G proteins have helped to unravel the intricacies of ligand binding. Similarly, structural and biochemical analyses of heterotrimeric G proteins have affirmed our understanding of the mechanism underlying effector interactions and GTPase activity. Our recent crystal structure of the ®2-adrenergic receptor (®2AR) in a complex with the stimulatory G protein, Gs, trapped in its nucleotide-free state, in particular, has now provided insight into the physical relationship between G proteins and GPCRs. Analysis of the structural data, along with pharmacological and biochemical data, have helped to delineate how hormone binding to GPCRs leads to GDP release on G proteins, the principle step that precedes GTP binding and G protein activation. Here we describe the functional relationship between the receptor and G protein leading to G protein activation and the initiation of cell signaling.
Host: CHRISTOPHER EVANS, PH.D.
Department of Psychiatry and Biobehavioral Sciences, UCLA
12:00pm Neuroscience Research Building (NRB) Auditorium, UCLA
Light refreshments served 1/2 hour prior to start of lecture